TY - JOUR T1 - Diagnostic performance of 18F-FDG PET/CT to diagnose lung cancer in idiopathic interstitial pneumonia patients JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1474 LP - 1474 VL - 57 IS - supplement 2 AU - Suk Hyun Lee AU - Changhwan Sung AU - Hyo Sang Lee AU - Jin-Sook Ryu Y1 - 2016/05/01 UR - http://jnm.snmjournals.org/content/57/supplement_2/1474.abstract N2 - 1474Objectives Patients with idiopathic interstitial pneumonia (IIP) are at increased risk of lung cancer (1). Because these patients often have poor pulmonary function and are vulnerable to pneumothorax (2), noninvasive diagnosis of lung cancer using imaging modalities is clinically relevant. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is highly accurate in diagnosing lung cancer (3), though accuracy is not high in endemic areas with infectious lung disease (4). Because patients with IIP also have increased risk of infection (5), we evaluated diagnostic performance of 18F-FDG PET/CT to diagnose lung cancer in patients with IIP.Methods We retrospectively reviewed 38 pulmonary nodules 蠅10mm in 36 IIP patients (34 men, 2 women; mean age=64.9±7.3 years; size=16.3±4.7 mm; biopsy proven IIP=14, clinicoradiologic IIP=22) who underwent chest CT followed by 18F-FDG PET/CT between 2004 and 2013. Maximal standardized uptake values (SUVmax) of suspicious nodules were used in the receiver operating characteristic (ROC) curve analysis to obtain an optimal cutoff value and parameters of diagnostic accuracy. Diagnostic gold standard was pathology or clinical follow-up results.Results Twenty-three (60.5%) nodules were malignant (squamous cell carcinoma=12, adenocarcinoma=6, small cell carcinoma=3, non-small cell carcinoma=1, large cell neuroendocrine carcinoma=1), and 15 (39.5%) were benign. The area under the ROC curve was 0.916. The optimal SUVmax cutoff value was 1.7, and the corresponding sensitivity, specificity, positive predictive value, and negative predictive value were 87.0%, 86.7%, 90.9%, and 81.3%, respectively.Conclusions Diagnostic performance of 18F-FDG PET/CT in patients with IIP is comparable to the diagnostic performance in patients without IIP. 18F-FDG PET/CT may be useful in selecting high-risk nodules that need lung biopsy. $$graphic_B6BD98A7-7DF7-4EE9-99CF-080F600EE41E$$ View this table:Patient characteristics of 38 pulmonary nodules in 36 patients with IIP ER -