RT Journal Article
SR Electronic
T1 Imaging Patients with Breast and Prostate Cancers Using Combined 18F NaF/18F FDG and TOF simultaneous PET/ MRI
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1416
OP 1416
VO 57
IS supplement 2
A1 Sonni, Ida
A1 Minamimoto, Ryogo
A1 Loening, Andreas
A1 Taviani, Valentina
A1 Jamali, Mehran
A1 HATAMI, NEGIN
A1 Baratto, Lucia
A1 Wu, Fengyu
A1 Gambhir, Sanjiv
A1 Vasanawala, Shreyas
A1 Iagaru, Andrei
YR 2016
UL http://jnm.snmjournals.org/content/57/supplement_2/1416.abstract
AB 1416Objectives We previously reported the pilot evaluation of a simultaneous PET/MRI scanner with TOF capability (1), as well as the use of combined 18F NaF/18F FDG PET/CT in cancer patients (2,3). Here we prospectively compared the combined 18F NaF/18F FDG PET/ MRI against 99mTc-MDP bone scintigraphy in patients with breast and prostate cancers.Methods 30 patients referred for 99mTc-MDP bone scans were prospectively enrolled from Oct 2014 to Jan 2016. The cohort included 23 men with prostate cancer and 7 women with breast cancer, 41 - 85 year-old (average 65 ± 11). 18F NaF (0.7-2.2 mCi, mean: 1.1 mCi) and 18F FDG (3.6-5.5 mCi, mean: 4.2 mCi) were subsequently injected from separate syringes. The PET/MRI was done 6-30 days (average 9.3 ± 3.2) after bone scan. The whole body MRI protocol consisted of MRAC, T2-weighted, DWI, and contrast-enhanced T1-weighted imaging. Lesions detected with each test were tabulated and the results were compared.Results All patients tolerated the PET/MRI exam and PET image quality was diagnostic despite the marked reduction in the administered dosage of radiopharmaceuticals (80% less for 18F NaF and 67% less for 18F FDG compared to standard PET/CT protocols). 11 patients had no bone metastases identified on either scans. Bone scintigraphy and PET/MRI showed osseous metastases in 16 patients, but more numerous bone findings were noted on PET/MRI than on bone scintigraphy in 8 of these patients. 1 patient had a negative bone scan, but bone metastases were seen on PET/MRI. Lesions outside the skeleton were identified by PET/MRI in 3 patients.Conclusions The combined 18F NaF/18F FDG PET/MRI is superior to 99mTc-MDP scintigraphy for evaluation of skeletal disease extent. Further, it detected extra-skeletal disease that may change the management of these patients, while allowing a significant reduction in radiation exposure from lower dosages of PET radiopharmaceuticals administered. 18F NaF/18F FDG PET/MRI appears well suited for detection of metastases in patients with breast and prostate cancers.