PT - JOURNAL ARTICLE AU - Eid Adawi AU - Hadas Kosovezer AU - Chen Lahat AU - Barak Gallerman AU - Yaron Hefetz TI - Molecular Breast Imaging (MBI) guided biopsy - lesion targeting accuracy verification DP - 2016 May 01 TA - Journal of Nuclear Medicine PG - 1942--1942 VI - 57 IP - supplement 2 4099 - http://jnm.snmjournals.org/content/57/supplement_2/1942.short 4100 - http://jnm.snmjournals.org/content/57/supplement_2/1942.full SO - J Nucl Med2016 May 01; 57 AB - 1942Objectives The Biopsy Unit is an accessory for the GE Healthcare Discovery[asterisk] NM750b (D750b) gamma camera. It is intended for 3D lesion localization and guidance for interventional purposes, using gamma imaging, and providing accuracy of ±6.5mm in the needle direction (Z) and ±3.5mm in the orthogonal direction (XY). The aim of this work was to verify the overall lesion targeting accuracy of the system.Methods To determine the overall biopsy accuracy we independently tested: a) The lesion marking accuracy by users, and b) The mechanical accuracy. Lesion marking accuracy was tested on images acquired as part of the biopsy protocol, using a phantom with 5mm and 8mm lesions at respective depths of 30mm and 50mm, with a background-to-lesion uptake ratio of 1:20. The distance of the marked position (manual and semi-automated software assisted identification) from the known lesion center was measured. The acceptance criteria were: XY radial error<2.2mm and Z error < 4.0mm. Mechanical accuracy was tested via a full biopsy workflow on a gel phantom with physical consistency similar to human tissue, into which Tc99m target lesions were injected. As part of the biopsy clinical workflow, lesion targeting accuracy is verified using visual and quantitative information obtained by imaging a gadolinium verification rod simultaneously with the targeted lesion. For the purpose of the test, the distance between the marked position of the gadolinium source and the lesion was measured in 3D. The acceptance criteria were: XY radial error<2.2mm and Z error < 5.1mm.Results Lesion marking accuracy results of 15 users (manual and software-assisted identification) demonstrate with more than 90% certainty that more than 90% of markings fall within the acceptance criteria. Results obtained for 8mm lesions at 50mm depth were better compared to 5mm lesions at 30mm depth. Mechanical accuracy: 7 repetitions of the flow were performed, with different biopsy devices and system orientations. Maximal targeting errors: 1.8mm in XY and 2.0mm in Z direction.Conclusions The design concept of the D750b Biopsy Unit was proved to enable biopsy process within the defined accuracy.