RT Journal Article
SR Electronic
T1 Brain pet metabolic abnormalities in patients with long-lasting macrophagic myofasciitis
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1853
OP 1853
VO 57
IS supplement 2
A1 Van Der Gucht, Axel
A1 Sebaiti, Mehdi
A1 Guedj, Eric
A1 Kauv, Paul
A1 Yara, Sabrina
A1 Gherardi, Romain
A1 Verger, Antoine
A1 Bachoud-Levi, Anne-Catherine
A1 Authier, Francois-Jerome
A1 Itti, Emmanuel
YR 2016
UL http://jnm.snmjournals.org/content/57/supplement_2/1853.abstract
AB 1853Objectives Macrophagic myofasciitis (MMF) is an emerging condition with specific muscle lesions characterized by an abnormal long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Patients present with diffuse arthromyalgias, chronic fatigue, and cognitive dysfunction. The aim of this study was to characterize brain PET metabolic abnormalities in patients with aluminum hydroxide adjuvant-induced macrophagic myofasciitis, and relation with cognitive dysfunction.Methods FDG-PET brain imaging and a comprehensive battery of neuropsychological tests were performed in 100 consecutive MMF patients (mean age, 45.9 ± 11.8 y; women, 74%) followed in our Reference Center for Rare Neuromuscular Diseases. Images were analyzed using statistical parametric mapping (SPM12). Using ANCOVA analysis, all FDG-PET brain images of MMF patients were compared to normal reference samples from 44 healthy subjects matched for age (p=0.87) and gender (p=0.88) with the whole population of patients (mean age, 45.4 ± 16 y; women, 73%). All results were collected at a P-value < 0.005 at the voxel level, for clusters k 蠅 200 voxels (corrected for cluster volume) with adjustment for age and gender. The neuropsychological assessment identified four categories of patients with: (i) no significant cognitive impairment (n=42); (ii) frontal sub-cortical (FSC) dysfunction (n=29); (iii) papezian dysfunction (n=22); and (iv) callosal disconnection (n=7).Results In comparison with healthy subjects, ANCOVA analysis of the whole population of patients with MMF exhibited a pattern of hypometabolism (p<0.001) involving occipital lobes, temporal lobes, limbic system, cerebellum and frontoparietal cortices. The subgroup of patients with FSC dysfunction exhibited larger extents of involved area (35223 voxels vs. 13680 voxels in the subgroup with papezian dysfunction and 5453 voxels in patients without cognitive impairment). Not significant result was obtained in the last subgroup due to its small effective population size.Conclusions Our study identified a cerebral glucose metabolic biomarker in patients with long-lasting aluminum hydroxide-induced MMF. The pattern appeared mostly marked in MMF patients with FSC dysfunction. $$graphic_A36A078B-44DB-4E22-A3E4-66756F066E7D$$