PT  - JOURNAL ARTICLE
AU  - ZHANG, JIANHUA
AU  - FAN, YAN
AU  - Fu, Zhanli
AU  - Zhang, Xuchu
AU  - Liu, Meng
AU  - Di, Lijuan
AU  - Wang, Rongfu
TI  - Role of 18F-FDG PET/CT in detection of Richter's transformation of small lymphocytic lymphoma/chronic lymphocytic leukemia
DP  - 2016 May 01
TA  - Journal of Nuclear Medicine
PG  - 1614--1614
VI  - 57
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/57/supplement_2/1614.short
4100  - http://jnm.snmjournals.org/content/57/supplement_2/1614.full
SO  - J Nucl Med2016 May 01; 57
AB  - 1614Objectives To investigate the role of 18F-FDG PET/CT in detection of Richter's transformation (RT) of small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL)Methods Twelve patients with SLL/CLL underwent 18F-FDG PET/CT between Jul 2010 and Nov 2015 were retrospectively analyzed. FDG avid lesions with a maximum standardized uptake value (SUVmax) of greater than 5 were considered highly suggestive of RT. The diagnosis of RT was based on the histopathological examination.Results All patients (8 males and 4 females) had the history of SLL/CLL ranged from 2 years to 11 years. Four patients underwent RT to diffuse large B-cell lymphoma, PET/CT detected sites of increased FDG uptake with SUVmax >5 in 3 patients(3/4, 75%), 1 patient has false-negative PET/CT findings. No patient had false-positive PET/CT findings and PET/CT correctly excluded RT in the other 8 patients. The overall sensitivity, specificity and accuracy of PET/CT for RT of SLL/CLL were 75%, 100% and 91.6%, respectively.Conclusions According to the preliminary data, 18F-FDG PET/CT has high accuracy for detection of RT of SLL/CLL. PET/CT can exclude the diagnosis of RT with a high degree of confidence in patients with SLL/CLL.