PT - JOURNAL ARTICLE AU - Jeong, Ju Hye AU - Jeong, Shin Young AU - Lee, Sang-Woo AU - Lee, Jaetae AU - Ahn, Byoeng-Cheol TI - Prognostic value of metabolic activity measured by 18F-FDG PET/CT in Patients with Multiple Myeloma DP - 2016 May 01 TA - Journal of Nuclear Medicine PG - 1617--1617 VI - 57 IP - supplement 2 4099 - http://jnm.snmjournals.org/content/57/supplement_2/1617.short 4100 - http://jnm.snmjournals.org/content/57/supplement_2/1617.full SO - J Nucl Med2016 May 01; 57 AB - 1617Objectives The aim of this study was to determine whether maximum standardized uptake value (SUVmax), whole body metabolic tumor volume (WBMTV) and whole body total lesion glycolysis (WBTLG) measured by pretreatment 18F-FDG PET/CT can be used in the prediction of overall survival in multiple myeloma (MM) patients.Methods From January 2008 to June 2014, twenty two patients (13 men, 9 women; mean age±SD, 62.55±11.62 y) with newly-diagnosed MM who underwent pretreatment 18F-FDG PET/CT were retrospectively evaluated. In lesions showing SUVmax > 2.5, a fixed threshold value of 40% of maximum uptake was used to determine tumor volume of interest (VOI) on PET image; SUVmax, MTV and TLG were calculated automatically. The WBMTV and WBTLG of each patient were defined as the sum of MTV and TLG of all focal lesions. Patients were treated and then subjected to a median follow-up period of 34 months (range 6-92 months).Results The 3-year overall survival (OS) was 69% and 7 patients died from the disease during the follow-up period. In the 22 patients studied, the range of SUVmax, WBMTV and WBTLG were 3.09-19.5, 0.7-815 cm3 and 1.56-4296.58 g, respectively. Receiver operating characteristic curve analysis showed cut-off values for SUVmax, WBMTV and WBTLG of 7.32, 149.8 cm3 and 701.65g, respectively. Univariate analysis showed that elevated serum LDH level (hazard ratio(HR)=14.38, p<0.0001), extramedullary involvement(HR=14.38, p<0.0001), the number of focal lesions (greater than 10)(HR=4.75, p=0.04), SUVmax (HR=8.35, p=0.02), WBMTV (HR=5.71, p=0.02) and WBTLG (HR=7.35, p=0.004) were significant predictors of OS. However, among these factors, there was no statistically significant predictor for OS on multivariate analysis.Conclusions Our results suggested that the PET parameters obtained from pretreatment PET/CT could play a potential role for prediction of overall survival in MM patients, same as well-known predictor (LDH level, extramedullary involvement and the number of focal lesions) although there was no statistically significant in multivariate analysis. Our study included only a small number of patients, and thus, further studies with larger patient cohorts are needed.