RT Journal Article SR Electronic T1 Longitudinal Decline of Striatal Subregional F-18 FP-CIT Uptake in Parkinson’s Disease JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 69 OP 69 VO 57 IS supplement 2 A1 Sung, Changhwan A1 Kim, JaeSeung A1 Oh, Minyoung A1 Oh, Seung Jun A1 Lee, Sang Ju A1 Oh, Jungsu YR 2016 UL http://jnm.snmjournals.org/content/57/supplement_2/69.abstract AB 69Objectives Dopamine transporter (DAT) imaging such as F-18 FP-CIT PET has been suggested to a useful imaging biomarker for the progression of Parkinson’s disease (PD). We investigated the characteristics of the longitudinal decline of striatal F-18 FP-CIT uptake in PD.Methods We reviewed retrospectively 25 patients with PD (52±12 yr, M/F: 13/12, H&Y stage: 1.4±0.6) and 7 Non-PD (69±7yr, M/F: 1/6, essential tremor, 3 drug induced Parkinsonism). All patients underwent F-18 FP-CIT PET scans at the initial diagnosis and follow-up (47±17mo). PET images were spatially normalized and analyzed with 8 striatal subregional and 1 occipital VOI templates. We measured the specific to non-specific binding ratio (SNBR) of striatal subregions. And we calculated the absolute annual reduction (AAR) and relative annual reduction (%RAR= 100×AAR/initial SNBR) of subregional SNBRs.Results Total striatal SNBRs (4.1±1.2) in patients with PD were significantly lower than those (6.6±0.9) in non-PD (P<0.001), and the difference was most significant in the posterior putamen. Both AAR (0.3±0.2/yr vs 0.1±0.2/yr, P=0.002) and %RAR (7.3±3.8%/yr vs 1.0±3.1%/yr, P<0.001) of total striatal SNBRs were significantly greater in PD than in non-PD. There were no significant differences in AAR (0.3±0.1/yr vs 0.3±0.2/yr, P>0.05) and %RAR (7.5±3.6%/yr vs 7.1±4.2%/yr, P>0.05) of total striatal SNBRs between elderly-onset PD and young-onset PD. AARs of striatal subregions were greater in PD with HY stage 1 than other more advanced PD, especially in the ipsilateral posterior putamen (0.32±0.15/yr vs 0.20±0.06/yr, P=0.032). In contrast, %RARs were smaller in PD with initial HY stage 1. Disease duration showed significant correlation with AAR (r=-0.45, P=0.033) but not with %RAR (r=0.16, P=0.475) of the ipsilateral posterior putamen.Conclusions The longitudinal decline of striatal F-18 FP-CIT uptake in PD was non-linear and 7times faster than that of non-PD, with the different annual decline rate among striatal subregions.