TY - JOUR T1 - Usefulness of respiratory gated F-18-FDG PET/CT in differentiated between lung cancer and non-lung cancer patients JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1884 LP - 1884 VL - 57 IS - supplement 2 AU - Jihyun Kim AU - Ho-young Lee AU - Sukki Cho Y1 - 2016/05/01 UR - http://jnm.snmjournals.org/content/57/supplement_2/1884.abstract N2 - 1884Objectives The purpose of this study is to evaluate the usefulness of respiratory gating F-18-FDG PET/CT acquisition to differentiate between lung cancer and non-lung cancer patients through quantitative analysis.Methods Seventy-eight patients (M: F=55:23, Age=61.9±14.6) who underwent F-18-FDG PET/CT from April to October, 2015 with suspicious lung cancer were retrospectively enrolled for the study. F-18-FDG PET/CT evaluation was acquired using mCT Flow (Siemens, Knoxville, TN, USA) before treatments (surgery, chemotherapy, radiotherapy, or concurrent chemoradiotherapy). All the images were concurrently obtained respiratory gating and non-gating images from lung apex to lung base or to liver during whole body acquisition. All stages were defined by TNM staging from American Joint Committee on Cancer 7th edition. SUVmax, and SUVmean in all images were measured using AW volumshare5 software.Results Seventy-one of all patients were diagnosed lung cancer pathologically through percutaneous biopsy (NSCLC: SCLC=66:5). Seven patients with non-lung cancer went under outpatient follow up. In lung cancer patient, all lesions’ SUVmax and SUVmean in the gated mode were higher compared with those of the non-gated mode (SUVmax; 8.36±4.6:8.87±4.7, p-value <0.001, SUVmean; 4.42±3.0:4.50±3.0, p-value=0.046). Moreover, gated SUVmax was significantly higher than non-gated SUVmax in accordance with location, right lower lobe (8.69±4.5:8.18±4.3, p-value 0.001) and right middle lobe (8.85±4.7:8.31±4.5, p-value 0.18). According to stages, SUVmax in gated mode showed higher than those in non-gated mode (3.90±4.0:4.34±4.5, p-value 0.013) in Stage IA. In non-lung cancer group, only SUVmax showed significant difference between gated and non-gated mode images (SUVmax; 10.8±2.8:11.3±7.04, p-value <0.018, SUVmean; 7.4±3.4:7.7±3.4, p-value=0.553).Conclusions We showed that there was significant increase in SUVmax and SUVmean of lung cancer and SUVmax of non-lung cancer lesions of respiratory gated images compared with non-gated image. We could assumed that respiratory gated F-18-FDG PET/CT can be useful in the assessment of early stage, especially stage IA, and lower localized cancerous lesion. Therefore, the respiratory gating method in F-18-FDG PET/CT is able to provide improved the diagnostic performance of PET. ER -