TY - JOUR T1 - Effect of Time-of-Flight Reconstruction on SUVmax, SUVpeak, SUVaverage, and Tumor Volume in Newly Diagnosed Prostate Cancer with 18F Choline PET/MRI JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1991 LP - 1991 VL - 57 IS - supplement 2 AU - Brett Mollard AU - Spencer Behr AU - Youngho Seo AU - Randall Hawkins AU - Robert Flavell Y1 - 2016/05/01 UR - http://jnm.snmjournals.org/content/57/supplement_2/1991.abstract N2 - 1991Objectives Prostate cancer is often difficult to detect due to its small size. Recent advances in PET detector technology allows reconstruction utilizing time-of-flight post-processing, which has been shown to improve spatial resolution and image quality, particularly in obese patients. The purpose of this study is to compare SUVmax, SUVpeak, SUVaverage, and tumor volume for 18F choline PET/MRI in the evaluation of patients with newly diagnosed biopsy-proven high-grade prostate cancer compared to standard PET/MRI reconstruction without time-of-flight reconstruction.Methods From April 1, 2015 to October 30, 2015, 12 patients with biopsy proven prostate cancer were evaluated with 18F choline PET/MRI in this retrospective institutional review board-approved study. Twelve patients with newly diagnosed biopsy-proven prostate cancer underwent simultaneous 18F choline PET/MRI. Images were reviewed separately by 2 physicians with dual board certification in radiology and nuclear medicine, an abdominal imaging fellow with board certification in nuclear medicine, and a nuclear medicine fellow. SUVmax and SUVpeak were documented for dominant 18F choline avid lesions and SUVaverage was obtained of the pelvic muscle background for 1-6 minute and 7-30 minute PET acquisition data sets. TOF SUVs were compared to non-TOF SUVSs for 1-6 minute and 7-30 minute PET acquisition data sets. Subjective tumor volumes of the dominant prostate lesions were measured on 18F choline PET images with standard non-TOF and TOF post-processing for 1-6 minute and 7-30 minute PET acquisition data sets. Measurements were compared to pathologic specimens.Results TOF SUVmax and SUVpeak were significantly higher for 1-6 minute data sets (4-20% higher, p<0.05 for both SUVmax and SUVpeak). No significant difference was found for SUVmax or SUVpeak at the 7-30 minute data set. No statistical difference was found between TOF and non-TOF for SUVave. Subjective tumor volume by PET was significantly smaller than tumor volume at pathology for TOF and non-TOF at both 1-6 and 7-30 minute data sets (range 15-19% of, p<0.05).Conclusions Lesion SUVmax and SUVpeak were significantly higher for 1-6 minute TOF PET acquisition data sets. No significant effect was found for 7-30 minute data sets or pelvic muscle background SUVaverage for either 1-6 or 7-30 minute data sets. Subjective tumor volume by PET was significantly less than pathologic tumor volume for all data sets. ER -