RT Journal Article
SR Electronic
T1 Effect of Cocaine Abuse on Baseline Lung FDG uptake in Patients Receiving Highly Active Antiretroviral Therapy
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1732
OP 1732
VO 57
IS supplement 2
A1 Pourhassan Shamchi, Sara
A1 Gholami, Saeid
A1 Houshmand, Sina
A1 Werner, Thomas
A1 Silverman, Randee
A1 Kenney, Thomas
A1 Alavi, Abass
A1 Tebas, Pablo
YR 2016
UL http://jnm.snmjournals.org/content/57/supplement_2/1732.abstract
AB 1732Objectives Clinical studies have suggested that substance-abuse including cocaine abuse may adversely affect disease prognosis in HIV positive patients by increasing viral load, accelerating disease progression, and AIDS-related mortality even among patients adherent to antiretroviral therapy. Given the fact that FDG PET/CT is very sensitive to detect underlying infectious/inflammatory changes, we have examined the effect of cocaine abuse on the baseline lung FDG uptake in well-controlled HIV positive patients under antiretroviral therapy.Methods A prospective study has been performed and HIV positive patients with and without cocaine abuse receiving highly active antiretroviral therapy (HAART) with adequate viral load control (<200 copies/ml) were included. Lung fields were selected manually using placement of ROIs (regions of interest) over the bilateral lung parenchyma. Using these ROIs, SUV max and SUVmean for the whole lungs were calculated using Osirix software.Results 18 patients with current cocaine abuse and 17 control patients without cocaine abuse were included. The mean age of the patients with cocaine abuse was 47.0±9.3 years compared to 49.4± 5.5 for patients without cocaine abuse (p=0.36). There was 14 males (78%) among cocaine abusers as opposed to 13 males among controls (76%)(p=0.93). Mean lung SUVmax was 1.08±0.22 for cocaine abusers compared to 1.04±0.26 among controls (p=0.52). Mean SUVmean was 0.43±0.12 and 0.41± 0.15 for cocaine abusers and controls, respectively (p=0.62). No significant correlation was also observed between lung FDG uptake and patients’ CD4 or CD8 counts.Conclusions Based on these findings, cocaine abuse does not affect the lung FDG uptake in patients with well-controlled HIV infection with HAART therapy.