PT  - JOURNAL ARTICLE
AU  - Katsuhiko Kato
AU  - Yumiko Koshiba
AU  - Shinji Abe
AU  - Saki Tsuchiya
AU  - Masayuki Honda
AU  - Keita Kunimoto
AU  - Tetsuro Odagawa
AU  - Seiichi Yamamoto
AU  - Shinji Naganawa
TI  - Detection of urinary tract tumors by <sup>18</sup>F-FLT PET/CT
DP  - 2016 May 01
TA  - Journal of Nuclear Medicine
PG  - 1562--1562
VI  - 57
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/57/supplement_2/1562.short
4100  - http://jnm.snmjournals.org/content/57/supplement_2/1562.full
SO  - J Nucl Med2016 May 01; 57
AB  - 1562Objectives The aim of this study is to investigate the efficacy of 18F-FLT PET/CT for detection of primary and metastatic lesions of urinary tract tumors.Methods Twenty-one (15 men, 6 women) patients were examined by 18F-FLT PET/CT (Siemens Biograph 16). All the patients received surgical operation or biopsy and the tumor was diagnosed histopathologically.Results In 21 patients examined by 18F-FLT PET/CT, 12 were confirmed histopathologically to be urothelial cell carcinoma, 6 renal cell carcinoma, 2 retroperitoneal liposarcoma, and 1 bladder carcinoma. Five patients had lung metastases, 2 had lymph node metastases, and 1 had gallbladder cancer synchronously. In 7 of the 12 patients with urothelial carcinoma and 1 with bladder carcinoma, the primary tumor could not be detected due to retention of urine in the ureter and urinary excretion of 18F-FLT. In the other 5 patient with urothelial cell carcinoma, 2 with retroperitoneal liposarcoma, and 1 with renal cell carcinoma, the primary tumor could be detected due to lack of urinary excretion of 18F-FLT by renal insufficiency. 18F-FLT uptake in the tumor site expressed as SUVmax in 18F-FLT PET was 2.17-28.99 (mean±S.D. 98.51±11.50) in urothelial cancer, 1.65 in renal cell carcinoma, and 9.35 and 4.24 (6.8±3.61) in retroperitoneal liposarcoma. Lung metastases after nephrectomy for renal cell carcinoma in 5 patients could be detected (SUVmax: 3.24-6.44 (4.45±1.13)). Lymph node metastases in 5 patients also could be detected (SUVmax:2.16-6.35 (4.45±1.73)).Conclusions Usually, 18F-FLT PET/CT is not suitable for detection of the primary lesions of urinary tract tumors because of its urinary excretion, whereas their metastatic lesions can be detected by 18F-FLT PET/CT. Nevertheless, in patients whose urinary excretion of 18F-FLT is disturbed by renal failures, 18F-FLT PET/CT is useful for detection of the primary lesions of urinary tract tumors.