TY - JOUR T1 - Value of FDG-PET/CT and cardiac MR for the diagnosis and therapy monitoring in cardiac sarcoidosis. JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1684 LP - 1684 VL - 57 IS - supplement 2 AU - Brian SGARD AU - Hilario Nunes AU - Dominique Valeyre AU - Pierre-Yves Brillet AU - véronique Eder AU - Michael Soussan Y1 - 2016/05/01 UR - http://jnm.snmjournals.org/content/57/supplement_2/1684.abstract N2 - 1684Objectives Cardiac sarcoidosis (CS) is associated with a poor prognosis. There are currently no clear recommendations on imaging strategy. The objective of this study was to compare FDG-PET/CT (PET) and cardiac MR imaging (MR) for the diagnosis and therapy monitoring of CS.Methods We conducted a single-center retrospective study including 80 patients with histologically proven sarcoidosis and a suspicion of CS. PET after a low carbohydrate-high fat diet and MR were performed in all patients in a maximum time interval of two months. 70% of them (n=56) were followed clinically during therapy and classified in responder or non responder but also using both MR and PET. The findings of PET and MR, as well as the reversibility under treatment were compared. Moreover we followed up all the patient (n=80) with a time mean of follow up of 28 months with as primary outcome were cardiac death and symptomatic arrhythmia.Results 42,5% of patients (n = 34) had a MR (+) and 11% (n = 9) had a PET (+). 82% of patients (n=9) with PET (+) had also an MR (+), with myocardial lesions located in the same locations in all cases. Among patients, 27% (n=22) had residual physiological FDG uptake under therapy (diffuse, basal, papillary muscle). 80% (n=8) of patients with PET (+) were responder versus 39% (n=18) for the group with PET(-) and results of MRI didn’t show difference between responder and no responder patient. Moreover among patients having baseline MR (+) and PET (+), 33% (n=3/9) had improving lesions on MR and 100% (n=7/7) on PET. Among patients with MR (+) and PET (-), 22% (n=4/18) had improving on follow-up MR. Only 3 events during a time mean of follow up of 28 months of 80 patients : 2 in the group with MRI+ and 1 in the group with MRI-. All this patients had a PET-.Conclusions PET be able to identify inflammatory CS and potential reversibility under treatment. PET should be systematically associated with MR for improving lesion characterization. ER -