PT - JOURNAL ARTICLE AU - Jeong Won Lee AU - Kwanhyeong Jo AU - Arthur Cho AU - Sung Hoon Noh AU - Jong Doo Lee AU - Mijin Yun TI - Relationship Between <sup>18</sup>F-FDG Uptake on PET and Recurrence Patterns After Curative Surgical Resection in Patients with Advanced Gastric Cancer AID - 10.2967/jnumed.115.160580 DP - 2015 Oct 01 TA - Journal of Nuclear Medicine PG - 1494--1500 VI - 56 IP - 10 4099 - http://jnm.snmjournals.org/content/56/10/1494.short 4100 - http://jnm.snmjournals.org/content/56/10/1494.full SO - J Nucl Med2015 Oct 01; 56 AB - This study evaluated the predictive value of 18F-FDG PET for distant metastasis-free survival and peritoneal recurrence-free survival as well as recurrence-free survival and overall survival after curative surgical resection in patients with advanced gastric cancer (AGC). Methods: Two hundred seventy-nine patients with AGC who underwent preoperative 18F-FDG PET and subsequent curative surgical resection were included. The tumor–to–normal liver uptake ratio (TLR) of cancer lesions was measured, and the prognostic significance of TLR and tumor factors for distant metastasis-free survival, peritoneal recurrence-free survival, recurrence-free survival, and overall survival was assessed. Results: The 5-y recurrence-free survival, peritoneal recurrence-free survival, distant metastasis-free survival, and overall survival rates were 46.9%, 68.5%, 76.0%, and 58.1%, respectively. Depth of tumor invasion, lymph node metastasis, lymphovascular invasion, and TLR were independent prognostic factors for both recurrence-free survival and overall survival (P &lt; 0.05). For distant metastasis-free survival, lymphovascular invasion and TLR were independent risk factors (P &lt; 0.05). In patients with a TLR of 2.0 or less, the 5-y distant metastasis-free survival rate was 95.5%; in patients with a TLR greater than 2.0, the 5-y distant metastasis-free survival rate was 68.8%. For peritoneal recurrence-free survival, TLR showed no statistical significance (P = 0.7) whereas pT stage, lymph node metastasis, Lauren classification, and Bormann type were independent prognostic factors (P &lt; 0.05). Conclusion: 18F-FDG uptake of AGC is an independent prognostic factor for distant metastasis-free survival, recurrence-free survival, and overall survival. The possibility of distant metastasis during follow-up should be considered in patients with high 18F-FDG uptake.