RT Journal Article
SR Electronic
T1 TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between <sup>123</sup>I-CLINDE SPECT, <sup>18</sup>F-FET PET, and Gadolinium-Enhanced MR Imaging
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1386
OP 1390
DO 10.2967/jnumed.115.158998
VO 56
IS 9
A1 Jensen, Per
A1 Feng, Ling
A1 Law, Ian
A1 Svarer, Claus
A1 Knudsen, Gitte M.
A1 Mikkelsen, Jens D.
A1 de Nijs, Robin
A1 Larsen, Vibeke A.
A1 Dyssegaard, Agnete
A1 Thomsen, Gerda
A1 Fischer, Walter
A1 Guilloteau, Denis
A1 Pinborg, Lars H.
YR 2015
UL http://jnm.snmjournals.org/content/56/9/1386.abstract
AB Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4′-123I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT (123I-CLINDE) and amino acid transport imaging using O-(2-18F-fluoroethyl)-l-tyrosine PET (18F-FET) and investigate whether 123I-CLINDE is superior to 18F-FET in predicting progression of glioblastoma multiforme (GBM) at follow-up. Methods: Three patients with World Health Organization grade IV GBM were scanned with 123I-CLINDE SPECT, 18F-FET PET, and gadolinium-enhanced MR imaging. Molecular imaging data were compared with follow-up gadolinium-enhanced MR images or contrast-enhanced CT scans. Results: The percentage overlap between volumes of interest (VOIs) of increased 18F-FET uptake and 123I-CLINDE binding was variable (12%–42%). The percentage overlap of MR imaging baseline VOIs was greater for 18F-FET (79%–93%) than 123I-CLINDE (15%–30%). In contrast, VOIs of increased contrast enhancement at follow-up compared with baseline overlapped to a greater extent with baseline 123I-CLINDE VOIs than 18F-FET VOIs (21% vs. 8% and 72% vs. 55%). Conclusion: Our preliminary results suggest that TSPO brain imaging in GBM may be a useful tool for predicting tumor progression at follow-up and may be less susceptible to changes in blood–brain barrier permeability than 18F-FET. Larger studies are warranted to test the clinical potential of TSPO imaging in GBM, including presurgical planning and radiotherapy.