RT Journal Article
SR Electronic
T1 Relationship Between <sup>18</sup>F-FDG PET/CT Scans and <em>KRAS</em> Mutations in Metastatic Colorectal Cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1322
OP 1327
DO 10.2967/jnumed.115.160614
VO 56
IS 9
A1 Kenji Kawada
A1 Kosuke Toda
A1 Yuji Nakamoto
A1 Masayoshi Iwamoto
A1 Etsuro Hatano
A1 Fengshi Chen
A1 Suguru Hasegawa
A1 Kaori Togashi
A1 Hiroshi Date
A1 Shinji Uemoto
A1 Yoshiharu Sakai
YR 2015
UL http://jnm.snmjournals.org/content/56/9/1322.abstract
AB Several studies have shown that KRAS mutations in colorectal cancer (CRC) result in the lack of response to anti-epidermal growth factor receptor–based therapy; thus, KRAS mutational testing has been incorporated into routine clinical practice. However, 1 limitation of this test is the heterogeneity of KRAS status, which can be either intratumoral heterogeneity within an individual primary CRC or discordant KRAS status between a primary CRC and its corresponding metastases. We previously reported that 18F-FDG accumulation was significantly higher in primary CRCs with mutated KRAS than in those with wild-type KRAS. However, the clinical utility of the previous report has been limited because endoscopic biopsy for testing KRAS status is safe and feasible only in primary CRC. The purpose of this study was to investigate whether KRAS status is associated with 18F-FDG accumulation in metastatic CRC and whether 18F-FDG PET/CT scans can be used to predict the KRAS status of metastatic CRC. Methods: A retrospective analysis was performed on 55 metastatic CRC tumors that were identified by 18F-FDG PET/CT before surgical resection. Maximum standardized uptake value (SUVmax) of the respective metastatic tumor was calculated from 18F-FDG accumulation. Results: From the analysis with the 55 tumors, no significant correlation was found between SUVmax and KRAS status. We next analyzed only tumors larger than 10 mm to minimize the bias of partial-volume effect and found that SUVmax was significantly higher in the KRAS-mutated group than in the wild-type group (8.3 ± 4.1 vs. 5.7 ± 2.4, respectively; P = 0.03). Multivariate analysis indicated that SUVmax remained significantly associated with KRAS mutations (P = 0.04). KRAS status could be predicted with an accuracy of 71.4% when an SUVmax cutoff value of 6.0 was used. Conclusion: 18F-FDG accumulation into metastatic CRC was associated with KRAS status. 18F-FDG PET/CT scans may be useful for predicting the KRAS status of metastatic CRC and help in determining the therapeutic strategies against metastatic CRC.