RT Journal Article SR Electronic T1 PET Quantification of Tau Pathology in Human Brain with 11C-PBB3 JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1359 OP 1365 DO 10.2967/jnumed.115.160127 VO 56 IS 9 A1 Kimura, Yasuyuki A1 Ichise, Masanori A1 Ito, Hiroshi A1 Shimada, Hitoshi A1 Ikoma, Yoko A1 Seki, Chie A1 Takano, Harumasa A1 Kitamura, Soichiro A1 Shinotoh, Hitoshi A1 Kawamura, Kazunori A1 Zhang, Ming-Rong A1 Sahara, Naruhiko A1 Suhara, Tetsuya A1 Higuchi, Makoto YR 2015 UL http://jnm.snmjournals.org/content/56/9/1359.abstract AB Tau accumulation in the brain is a pathologic hallmark of Alzheimer disease and other tauopathies. Quantitative visualization of tau pathology in humans can be a powerful method as a diagnostic aid and for monitoring potential therapeutic interventions. We established methods of PET quantification of tau pathology with 11C-PBB3 (2-((1E,3E)-4-(6-(11C-methylamino)pyridin-3-yl)buta-1,3-dienyl) benzo[d]thiazol-6-ol), considering its radiometabolite entering the brain. Methods: Seven Alzheimer disease patients and 7 healthy subjects underwent dynamic 11C-PBB3 PET scanning. Arterial blood was sampled to obtain the parent and metabolite input functions. Quantification of 11C-PBB3 binding was performed using dual-input models that take the brain metabolite activity into consideration, traditional single-input models without such considerations, and the reference tissue model (MRTMO) and standardized uptake value ratio (SUVR). The cerebellar cortex was used as the reference tissue for all methods. Results: The dual-input graphical models estimated binding parameter () stably (∼0.36 in high-binding regions). The MRTMO matched the corresponding by the dual-input graphical model (r2 = 1.00). SUVR minus 1 correlated well with MRTMO (r2 > 0.97). However, BPND by the single-input models did not correlate with by the dual-input graphical model (r2 = 0.04). Conclusion: The dual-input graphical model is consistent with the reference tissue and SUVR-1, suggesting that these parameters can accurately quantify binding of 11C-PBB3 despite the entry of its radiometabolites into the brain.