TY - JOUR T1 - Chinese data of efficacy of low- and high-dose of iodine-131 for the ablation of thyroid remnant JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1451 LP - 1451 VL - 57 IS - supplement 2 AU - Fang Feng AU - Chao Ma AU - Hui Wang Y1 - 2016/05/01 UR - http://jnm.snmjournals.org/content/57/supplement_2/1451.abstract N2 - 1451Objectives Chinese data of efficacy of low- and high-dose of radioiodine for thyroid remnant is still absent. The aim of the study is to investigate whether the low-dose of radioiodine is as effective as high dose for remnant ablation in Chinese patients.Methods Patients presenting for radioiodine ablation in our department were included. Inclusion criteria were an age of 16 years or older; total or near total thyroidectomy; tumor-node-metastasis (TNM) stage of pT1-3 and any N stage, M0. All patients were randomly allocated to the high-dose group of 3700 MBq and low-dose group of 1850 MBq for remnant ablation. The response to treatment was defined as successful or unsuccessful after 6-9 month interval. Ablation was considered to be successful if patients fulfilled the following criteria: no tracer uptake in the thyroid bed on diagnosis whole body scan and negative level of serum Tg-off. A statistically significant difference was considered when P value is less than 0.05. SPSS version 19.0 was used for statistical analysis.Results There were 327 patients enrolled between January 2012 and December 2014. More than 99% had papillary cancer. Data could be analyzed for 278 cases (mean age: 44 years old, 71.6% women), low-dose group, 155 patients, and high-dose group, 123 patients. The rate of initial successful ablation was 84.2 % in all patients, 82.6% in the low-dose group, and 86.2% in the high-dose group. There was no difference between the two groups (P=0.509). In a multivariate model, only the age of patients and the baseline serum TgAb-off value were the significant factors that independently had an influence on the odds of successful ablation in our patients. There was no difference in short-term adverse effects between the two groups (P>0.05).Conclusions In Chinese patients with differentiated thyroid carcinoma, the low dose of 1850 MBq radioiodine activity is as effective as high dose of 3700 MBq for thyroid remnant ablation. Table 1. Baseline Characteristics of the Patients. View this table: There were no significant differences between clinical parameters, histopathology, tumor stage, postsurgical serum TSH, Tg, and anti-Tg antibody levels between the two groups. Table 2. Likelihood ratios of the independent predictors for achieving complete ablation of remnant thyroid tissue by the first dose of radioiodine therapy on the basis of a binary logistic regression procedure as a model for prediction of outcome CI, confidence interval; NTT, near-total thyroidectomy; OR, odds ratio; Tg, thyroglobulin; TSH, thyroid stimulating hormone; TT, total thyroidectomy View this table: ER -