RT Journal Article
SR Electronic
T1 Effect of Attenuation Correction on Regional Quantification Between PET/MR and PET/CT: A Multicenter Study Using a 3-Dimensional Brain Phantom
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 818
OP 824
DO 10.2967/jnumed.115.166165
VO 57
IS 5
A1 Jarmo Teuho
A1 Jarkko Johansson
A1 Jani Linden
A1 Adam Espe Hansen
A1 Søren Holm
A1 Sune H. Keller
A1 Gaspar Delso
A1 Patrick Veit-Haibach
A1 Keiichi Magota
A1 Virva Saunavaara
A1 Tuula Tolvanen
A1 Mika Teräs
A1 Hidehiro Iida
YR 2016
UL http://jnm.snmjournals.org/content/57/5/818.abstract
AB A spatial bias in brain PET/MR exists compared with PET/CT, because of MR-based attenuation correction. We performed an evaluation among 4 institutions, 3 PET/MR systems, and 4 PET/CT systems using an anthropomorphic brain phantom, hypothesizing that the spatial bias would be minimized with CT-based attenuation correction (CTAC). Methods: The evaluation protocol was similar to the quantification of changes in neurologic PET studies. Regional analysis was conducted on 8 anatomic volumes of interest (VOIs) in gray matter on count-normalized, resolution-matched, coregistered data. On PET/MR systems, CTAC was applied as the reference method for attenuation correction. Results: With CTAC, visual and quantitative differences between PET/MR and PET/CT systems were minimized. Intersystem variation between institutions was +3.42% to −3.29% in all VOIs for PET/CT and +2.15% to −4.50% in all VOIs for PET/MR. PET/MR systems differed by +2.34% to −2.21%, +2.04% to −2.08%, and −1.77% to −5.37% when compared with a PET/CT system at each institution, and these differences were not significant (P ≥ 0.05). Conclusion: Visual and quantitative differences between PET/MR and PET/CT systems can be minimized by an accurate and standardized method of attenuation correction. If a method similar to CTAC can be implemented for brain PET/MRI, there is no reason why PET/MR should not perform as well as PET/CT.