TY - JOUR T1 - Prognostic Significance of <sup>18</sup>F-FDG Uptake in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization or Concurrent Chemoradiotherapy: A Multicenter Retrospective Cohort Study JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 509 LP - 516 DO - 10.2967/jnumed.115.167338 VL - 57 IS - 4 AU - Jeong Won Lee AU - Jin Kyoung Oh AU - Yong An Chung AU - Sae Jung Na AU - Seung Hyup Hyun AU - Il Ki Hong AU - Jae Seon Eo AU - Bong-Il Song AU - Tae-sung Kim AU - Do Young Kim AU - Seung Up Kim AU - Dae Hyuk Moon AU - Jong Doo Lee AU - Mijin Yun Y1 - 2016/04/01 UR - http://jnm.snmjournals.org/content/57/4/509.abstract N2 - This study aimed to assess the prognostic value of 18F-FDG uptake in hepatocellular carcinoma (HCC) patients who had transarterial chemoembolization (TACE) or concurrent intraarterial chemotherapy with external-beam radiotherapy (CCRT) and to compare the prognosis between patients treated with TACE and those with CCRT according to 18F-FDG uptake. Methods: Two hundred fourteen intermediate–to–advanced-stage HCC patients without extrahepatic metastasis who underwent staging 18F-FDG PET/CT before TACE (153 patients) or CCRT (61 patients) were recruited from 7 hospitals. Progression-free survival (PFS) and overall survival (OS) were compared using an optimal cutoff value for tumor-to-normal liver uptake ratio (TLR). Further, PFS and OS were compared according to treatment modalities (TACE vs. CCRT) using the same TLR cutoff value. Results: On multivariate analysis, age and TLR were independent prognostic factors for PFS (P &lt; 0.050). For OS, Child–Pugh classification and TLR were independent prognostic factors (P &lt; 0.050). When the TLR was greater than 2.0, patients treated with CCRT showed significantly better PFS and OS than those treated with TACE after adjusting for tumor size and number (P = 0.014, for all). In contrast, there was no significant difference in PFS and OS between patients treated with TACE or CCRT when the TLR was 2.0 or less. Conclusion: 18F-FDG uptake was an independent prognostic factor for PFS and OS in HCC patients treated with TACE or CCRT. Especially, in HCCs with high 18F-FDG uptake, patients treated with CCRT showed better survival than those treated with TACE. 18F-FDG PET/CT may help determine the treatment modality for intermediate–to–advanced-stage HCCs. ER -