TY - JOUR T1 - Evaluation of Atlas-Based Attenuation Correction for Integrated PET/MR in Human Brain: Application of a Head Atlas and Comparison to True CT-Based Attenuation Correction JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 215 LP - 220 DO - 10.2967/jnumed.115.159228 VL - 57 IS - 2 AU - Tetsuro Sekine AU - Alfred Buck AU - Gaspar Delso AU - Edwin E.G.W. ter Voert AU - Martin Huellner AU - Patrick Veit-Haibach AU - Geoffrey Warnock Y1 - 2016/02/01 UR - http://jnm.snmjournals.org/content/57/2/215.abstract N2 - Attenuation correction (AC) for integrated PET/MR imaging in the human brain is still an open problem. In this study, we evaluated a simplified atlas-based AC (Atlas-AC) by comparing 18F-FDG PET data corrected using either Atlas-AC or true CT data (CT-AC). Methods: We enrolled 8 patients (median age, 63 y). All patients underwent clinically indicated whole-body 18F-FDG PET/CT for staging, restaging, or follow-up of malignant disease. All patients volunteered for an additional PET/MR of the head (additional tracer was not injected). For each patient, 2 AC maps were generated: an Atlas-AC map registered to a patient-specific liver accelerated volume acquisition-Flex MR sequence and using a vendor-provided head atlas generated from multiple CT head images and a CT-based AC map. For comparative AC, the CT-AC map generated from PET/CT was superimposed on the Atlas-AC map. PET images were reconstructed from the list-mode raw data from the PET/MR imaging scanner using each AC map. All PET images were normalized to the SPM5 PET template, and 18F-FDG accumulation was quantified in 67 volumes of interest (VOIs; automated anatomic labeling atlas). Relative difference (%diff) between images based on Atlas-AC and CT-AC was calculated, and averaged difference images were generated. 18F-FDG uptake in all VOIs was compared using Bland–Altman analysis. Results: The range of error in all 536 VOIs was −3.0%–7.3%. Whole-brain 18F-FDG uptake based on Atlas-AC was slightly underestimated (%diff = 2.19% ± 1.40%). The underestimation was most pronounced in the regions below the anterior/posterior commissure line, such as the cerebellum, temporal lobe, and central structures (%diff = 3.69% ± 1.43%, 3.25% ± 1.42%, and 3.05% ± 1.18%), suggesting that Atlas-AC tends to underestimate the attenuation values of the skull base bone. Conclusion: When compared with the gold-standard CT-AC, errors introduced using Atlas-AC did not exceed 8% in any brain region investigated. Underestimation of 18F-FDG uptake was minor (<4%) but significant in regions near the skull base. ER -