RT Journal Article SR Electronic T1 The Impact of 68Ga-DOTATATE PET/CT Imaging on Management of Patients with Neuroendocrine Tumors: Experience from a National Referral Center in the United Kingdom JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 34 OP 40 DO 10.2967/jnumed.115.166017 VO 57 IS 1 A1 Evangelia Skoura A1 Sofia Michopoulou A1 Mullan Mohmaduvesh A1 Emmanouil Panagiotidis A1 Mohammed Al Harbi A1 Christos Toumpanakis A1 Omar Almukhailed A1 Irfan Kayani A1 Rizwan Syed A1 Shaunak Navalkissoor A1 Peter J. Ell A1 Martyn E. Caplin A1 Jamshed Bomanji YR 2016 UL http://jnm.snmjournals.org/content/57/1/34.abstract AB 68Ga-DOTATATE PET/CT scanning is a widely accepted method for imaging of neuroendocrine tumors. This cross-sectional study was performed to review the first 8 y of patient data from a large 68Ga-DOTATATE PET/CT database in order to establish the impact of the modality on patient treatment and survival. Methods: Demographic data, clinical outcome, survival, and change in management after 68Ga-DOTATATE PET/CT were evaluated. Results: Between May 2005 and August 2013, 1,258 68Ga-DOTATATE PET/CT scans were obtained in 728 patients with confirmed or suspected neuroendocrine tumors. In most patients, the primary site was located in the midgut (26.4%). Analysis of NET grading in patients with known histopathologic data revealed that 35.7% had NET grade G1, 12.2% G2, and 8.7% G3. The most common indications for 68Ga-DOTATATE PET/CT were follow-up (24.4%) and initial tumor staging (23.4%). Of the 1,258 68Ga-DOTATATE PET/CT scans completed, 75.7% were positive and 24.3% negative; there were 14 false-positive and 29 false-negative scans. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 97%, 95.1%, 96.6%, 98.5%, and 90.4%, respectively. In 40.9% of patients, the treatment plan was changed after the scans, owing mainly to new, unexpected findings. Statistically significant differences in survival were shown between patients with G1, G2, and G3 grade tumors (P < 0.0001) and also between patients with bone metastasis versus patients with soft-tissue metastasis (P < 0.0001). Conclusion: 68Ga-DOTATATE PET/CT scanning is safe and influences management in a large proportion of patients. Prognosis was dependent on tumor grade, and the presence of bone metastasis was associated with worse overall survival.