PT  - JOURNAL ARTICLE
AU  - Ravi Vij
AU  - Kathryn J. Fowler
AU  - Monica Shokeen
TI  - New Approaches to Molecular Imaging of Multiple Myeloma
AID  - 10.2967/jnumed.115.163808
DP  - 2016 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 1--4
VI  - 57
IP  - 1
4099  - http://jnm.snmjournals.org/content/57/1/1.short
4100  - http://jnm.snmjournals.org/content/57/1/1.full
SO  - J Nucl Med2016 Jan 01; 57
AB  - Molecular imaging plays an important role in detection and staging of hematologic malignancies. Multiple myeloma (MM) is an age-related hematologic malignancy of clonal bone marrow plasma cells characterized by destructive bone lesions and is fatal in most patients. Traditional skeletal survey and bone scans have sensitivity limitations for osteolytic lesions manifested in MM. Progressive biomedical imaging technologies such as low-dose CT, molecularly targeted PET, MRI, and the functional–anatomic hybrid versions (PET/CT and PET/MRI) provide incremental advancements in imaging MM. Imaging with PET and MRI using molecularly targeted probes is a promising precision medicine platform that might successfully address the clinical ambiguities of myeloma spectrum diseases. The intent of this focus article is to provide a concise review of the present status and promising developments on the horizon, such as the new molecular imaging biomarkers under investigation that can either complement or potentially supersede existing standards.