RT Journal Article SR Electronic T1 Prognostic Value of Dual-Time-Point 18F-FDG PET for Idiopathic Pulmonary Fibrosis JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1869 OP 1875 DO 10.2967/jnumed.115.163360 VO 56 IS 12 A1 Umeda, Yukihiro A1 Demura, Yoshiki A1 Morikawa, Miwa A1 Anzai, Masaki A1 Kadowaki, Maiko A1 Ameshima, Shingo A1 Tsuchida, Tatsuro A1 Tsujikawa, Tetsuya A1 Kiyono, Yasushi A1 Okazawa, Hidehiko A1 Ishizaki, Takeshi A1 Ishizuka, Tamotsu YR 2015 UL http://jnm.snmjournals.org/content/56/12/1869.abstract AB The aim of this prospective study was to clarify whether dual-time-point 18F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. Methods: Fifty IPF patients underwent 18F-FDG PET examinations at 2 time points: 60 min (early imaging) and 180 min (delayed imaging) after 18F-FDG injection. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated, and then the results were compared with overall and progression-free survival. Results: A multivariate Cox proportional hazards model showed higher RI-SUV and higher extent of fibrosis score as independent predictors of shorter progression-free survival. The median progression-free survival for patients with negative RI-SUV was better than that for those with positive RI-SUV (27.9 vs. 13.3 mo, P = 0.0002). On the other hand, multivariate Cox analysis showed higher RI-SUV and lower forced vital capacity to be independent predictors of shorter overall survival. The 5-y survival rate for patients with negative RI-SUV was better than that for those with positive RI-SUV (76.8% vs. 14.3%, P = 0.00001). In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality (hazard ratio, 7.31; 95% confidence interval, 2.64–20.3; P = 0.0001). Conclusion: Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF.