PT - JOURNAL ARTICLE AU - John C. Stendahl AU - Albert J. Sinusas TI - Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 2: Radiolabeled Probes AID - 10.2967/jnumed.115.164145 DP - 2015 Nov 01 TA - Journal of Nuclear Medicine PG - 1637--1641 VI - 56 IP - 11 4099 - http://jnm.snmjournals.org/content/56/11/1637.short 4100 - http://jnm.snmjournals.org/content/56/11/1637.full SO - J Nucl Med2015 Nov 01; 56 AB - Nanoparticulate imaging agents and therapeutics have proven to be valuable tools in preclinical cardiovascular disease research. Because of their distinct properties and significant functional versatility, nanoparticulate imaging agents afford certain capabilities that are typically not provided by traditional small molecule agents. This review is the second in a two-part series covering nanoparticulate imaging agents and theranostics. It highlights current examples of radiolabeled nanoparticulate probes in preclinical cardiovascular research and demonstrates their utility in applications such as blood pool imaging and molecular imaging of ischemia, angiogenesis, atherosclerosis, and inflammation. These agents provide valuable insight into the molecular and cellular mechanisms of cardiovascular disease and illustrate both the limitations and the significant potential of nanoparticles in diagnostic and therapeutic applications. Further technologic development to improve performance, address safety concerns, and fulfil regulatory obligations is required for clinical translation of these emergent technologies.