PT - JOURNAL ARTICLE AU - Jennifer Renaud AU - Jens Huettges AU - Janet Gelbach AU - Erica Bush AU - Steven Port AU - Robert deKemp TI - <strong>Dynamic range is acceptable for myocardial blood flow quantification with the Scintron LSO 3D-PET system</strong> DP - 2015 May 01 TA - Journal of Nuclear Medicine PG - 1851--1851 VI - 56 IP - supplement 3 4099 - http://jnm.snmjournals.org/content/56/supplement_3/1851.short 4100 - http://jnm.snmjournals.org/content/56/supplement_3/1851.full SO - J Nucl Med2015 May 01; 56 AB - 1851 Objectives 3D-mode imaging is the standard for new commercial PET systems. Dynamic cardiac imaging for quantification of myocardial blood flow (MBF) with short-lived tracers such as Rb-82 requires accuracy to be maintained over a wide range of activities. We characterized the dynamic range of the recently released Scintron PET LSO system in 3D mode.Methods 1000 MBq of Rb-82 was injected into the myocardium of a cardiac insert in an anthropomorphic torso phantom simulating a 70 kg patient. Dynamic images (40 x 15s) were reconstructed using the vendor-supplied OSEM algorithm with all corrections enabled. Dynamic range was defined at the maximum activity in the myocardium with &lt;10% bias in accuracy as a function of dead-time factor (DTF) and max coincidence count-rate (prompt+delayed) which can be monitored in real-time during patient scans. Five patient scans with 5 MBq/kg of Rb-82 injected activity were performed to measure MBF and confirm DTF and count-rate values remained within the accurate range during typical clinical use. Image quality was also evaluated.Results To maintain accuracy, the maximum allowable DTF and count-rate from the phantom scan were 1.7 (43% dead-time) and 3.1 million counts/second (Mcps). For the 5 patient scans, peak DTF and count-rate were: 1.5±0.3 and 1.6±1.2 Mcps, suggesting that recorded activity values remained within the accurate range. The resulting LV-mean MBF values from a 1-compartment model were in the expected normal range (0.5-1.0 mL/min/g) for all 5 patients at rest (MBF = 0.9±0.2 mL/min/g). Excellent diagnostic image quality was observed in all cases.Conclusions Quantitative 3D cardiac imaging appears feasible on the Scintron PET LSO scanner within the recommended ranges for peak DTF and scanner count-rate. Preliminary clinical patient studies confirm reasonable MBF values at rest within the reported normal range.