RT Journal Article
SR Electronic
T1 Assessment of Traumatic Brain Injury by Increased <sup>64</sup>Cu Uptake on <sup>64</sup>CuCl<sub>2</sub> PET/CT
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1252
OP 1257
DO 10.2967/jnumed.115.154575
VO 56
IS 8
A1 Fangyu Peng
A1 Otto Muzik
A1 Joshua Gatson
A1 Steven G. Kernie
A1 Ramon Diaz-Arrastia
YR 2015
UL http://jnm.snmjournals.org/content/56/8/1252.abstract
AB Copper is a nutritional trace element required for cell proliferation and wound repair. Methods: To explore increased copper uptake as a biomarker for noninvasive assessment of traumatic brain injury (TBI), experimental TBI in C57BL/6 mice was induced by controlled cortical impact, and 64Cu uptake in the injured cortex was assessed with 64CuCl2 PET/CT. Results: At 24 h after intravenous injection of the tracer, uptake was significantly higher in the injured cortex of TBI mice (1.15 ± 0.53 percentage injected dose per gram of tissue [%ID/g]) than in the uninjured cortex of mice without TBI (0.53 ± 0.07 %ID/g, P = 0.027) or the cortex of mice that received an intracortical injection of zymosan A (0.62 ± 0.22 %ID/g, P = 0.025). Furthermore, uptake in the traumatized cortex of untreated TBI mice (1.15 ± 0.53 %ID/g) did not significantly differ from that in minocycline-treated TBI mice (0.93 ± 0.30 %ID/g, P = 0.33). Conclusion: Overall, the data suggest that increased 64Cu uptake in traumatized brain tissues holds potential as a new biomarker for noninvasive assessment of TBI with 64CuCl2 PET/CT.