PT  - JOURNAL ARTICLE
AU  - Fangyu Peng
AU  - Otto Muzik
AU  - Joshua Gatson
AU  - Steven G. Kernie
AU  - Ramon Diaz-Arrastia
TI  - Assessment of Traumatic Brain Injury by Increased <sup>64</sup>Cu Uptake on <sup>64</sup>CuCl<sub>2</sub> PET/CT
AID  - 10.2967/jnumed.115.154575
DP  - 2015 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 1252--1257
VI  - 56
IP  - 8
4099  - http://jnm.snmjournals.org/content/56/8/1252.short
4100  - http://jnm.snmjournals.org/content/56/8/1252.full
SO  - J Nucl Med2015 Aug 01; 56
AB  - Copper is a nutritional trace element required for cell proliferation and wound repair. Methods: To explore increased copper uptake as a biomarker for noninvasive assessment of traumatic brain injury (TBI), experimental TBI in C57BL/6 mice was induced by controlled cortical impact, and 64Cu uptake in the injured cortex was assessed with 64CuCl2 PET/CT. Results: At 24 h after intravenous injection of the tracer, uptake was significantly higher in the injured cortex of TBI mice (1.15 ± 0.53 percentage injected dose per gram of tissue [%ID/g]) than in the uninjured cortex of mice without TBI (0.53 ± 0.07 %ID/g, P = 0.027) or the cortex of mice that received an intracortical injection of zymosan A (0.62 ± 0.22 %ID/g, P = 0.025). Furthermore, uptake in the traumatized cortex of untreated TBI mice (1.15 ± 0.53 %ID/g) did not significantly differ from that in minocycline-treated TBI mice (0.93 ± 0.30 %ID/g, P = 0.33). Conclusion: Overall, the data suggest that increased 64Cu uptake in traumatized brain tissues holds potential as a new biomarker for noninvasive assessment of TBI with 64CuCl2 PET/CT.