RT Journal Article
SR Electronic
T1 Beyond <sup>18</sup>F-FDG: Characterization of PET/CT and PET/MR Scanners for a Comprehensive Set of Positron Emitters of Growing Application—<sup>18</sup>F, <sup>11</sup>C, <sup>89</sup>Zr, <sup>124</sup>I, <sup>68</sup>Ga, and <sup>90</sup>Y
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1285
OP 1291
DO 10.2967/jnumed.115.156711
VO 56
IS 8
A1 A. Therese Soderlund
A1 Jasper Chaal
A1 Gabriel Tjio
A1 John J. Totman
A1 Maurizio Conti
A1 David W. Townsend
YR 2015
UL http://jnm.snmjournals.org/content/56/8/1285.abstract
AB This study aimed to investigate image quality for a comprehensive set of isotopes (18F, 11C, 89Zr, 124I, 68Ga, and 90Y) on 2 clinical scanners: a PET/CT scanner and a PET/MR scanner. Methods: Image quality and spatial resolution were tested according to NU 2-2007 of the National Electrical Manufacturers Association. An image-quality phantom was used to measure contrast recovery, residual bias in a cold area, and background variability. Reconstruction methods available on the 2 scanners were compared, including point-spread-function correction for both scanners and time of flight for the PET/CT scanner. Spatial resolution was measured using point sources and filtered backprojection reconstruction. Results: With the exception of 90Y, small differences were seen in the hot-sphere contrast recovery of the different isotopes. Cold-sphere contrast recovery was similar across isotopes for all reconstructions, with an improvement seen with time of flight on the PET/CT scanner. The lower-statistic 90Y scans yielded substantially lower contrast recovery than the other isotopes. When isotopes were compared, there was no difference in measured spatial resolution except for PET/MR axial spatial resolution, which was significantly higher for 124I and 68Ga. Conclusion: Overall, both scanners produced good images with 18F, 11C, 89Zr, 124I, 68Ga, and 90Y.