TY - JOUR T1 - <sup>18</sup>F-FDG PET/CT and Colorectal Cancer: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 989 LP - 994 DO - 10.2967/jnumed.115.156240 VL - 56 IS - 7 AU - Charles Marcus AU - Wael Marashdeh AU - Se Jin Ahn AU - Mehdi Taghipour AU - Rathan M. Subramaniam Y1 - 2015/07/01 UR - http://jnm.snmjournals.org/content/56/7/989.abstract N2 - The purpose of this study was to evaluate the added value of a fourth and subsequent follow-up PET/CT scans to clinical assessment and impact on patient management in patients with colorectal cancer. Methods: This was an institutional review board–approved, retrospective study. Eight hundred twenty-two patients with biopsy-proven colorectal cancer, who underwent 18F-FDG PET/CT, were identified from 2000 to 2012. Among these, 73 (8.9%) patients underwent 4 or more follow-up PET/CT scans, with a total of 313 fourth and subsequent follow-up PET/CT scans. Median follow-up from the fourth follow-up PET/CT scan was 41.7 mo. The added value of each follow-up PET/CT scan, for clinical assessment and the treatment changes subsequent to each follow-up PET/CT scan, was established. Overall survival prediction was established using Kaplan–Meier plots with a Mantel–Cox log-rank test. Results: Of the 313 fourth and subsequent follow-up PET/CT scans, 174 (55.6%) were interpreted as positive and 139 (44.4%) were interpreted as negative for recurrence or metastases. Thirty-four (46.6%) patients died during the study period. PET/CT identified recurrence or metastasis in 40.0% of scans obtained without prior clinical suspicion and ruled out disease in 23.6% of scans obtained with prior clinical suspicion. The PET/CT scan resulted in treatment change after 34.2% (107/313) of the scans. New treatment was initiated after 24.0% (75/313) of the scans, and treatment was changed after 8.0% (25/313) scans. There was a statistically significant difference in the overall survival between patients with a positive and all negative fourth and subsequent follow-up PET/CT scans at the patient level (log-rank, P = 0.001). Conclusion: The fourth and subsequent 18F-FDG PET/CT scans obtained after primary treatment completion add value to clinical assessment and the management plan and provide prognostic information in patients with colorectal cancer. ER -