@article {Marcus989, author = {Charles Marcus and Wael Marashdeh and Se Jin Ahn and Mehdi Taghipour and Rathan M. Subramaniam}, title = {18F-FDG PET/CT and Colorectal Cancer: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management}, volume = {56}, number = {7}, pages = {989--994}, year = {2015}, doi = {10.2967/jnumed.115.156240}, publisher = {Society of Nuclear Medicine}, abstract = {The purpose of this study was to evaluate the added value of a fourth and subsequent follow-up PET/CT scans to clinical assessment and impact on patient management in patients with colorectal cancer. Methods: This was an institutional review board{\textendash}approved, retrospective study. Eight hundred twenty-two patients with biopsy-proven colorectal cancer, who underwent 18F-FDG PET/CT, were identified from 2000 to 2012. Among these, 73 (8.9\%) patients underwent 4 or more follow-up PET/CT scans, with a total of 313 fourth and subsequent follow-up PET/CT scans. Median follow-up from the fourth follow-up PET/CT scan was 41.7 mo. The added value of each follow-up PET/CT scan, for clinical assessment and the treatment changes subsequent to each follow-up PET/CT scan, was established. Overall survival prediction was established using Kaplan{\textendash}Meier plots with a Mantel{\textendash}Cox log-rank test. Results: Of the 313 fourth and subsequent follow-up PET/CT scans, 174 (55.6\%) were interpreted as positive and 139 (44.4\%) were interpreted as negative for recurrence or metastases. Thirty-four (46.6\%) patients died during the study period. PET/CT identified recurrence or metastasis in 40.0\% of scans obtained without prior clinical suspicion and ruled out disease in 23.6\% of scans obtained with prior clinical suspicion. The PET/CT scan resulted in treatment change after 34.2\% (107/313) of the scans. New treatment was initiated after 24.0\% (75/313) of the scans, and treatment was changed after 8.0\% (25/313) scans. There was a statistically significant difference in the overall survival between patients with a positive and all negative fourth and subsequent follow-up PET/CT scans at the patient level (log-rank, P = 0.001). Conclusion: The fourth and subsequent 18F-FDG PET/CT scans obtained after primary treatment completion add value to clinical assessment and the management plan and provide prognostic information in patients with colorectal cancer.}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/56/7/989}, eprint = {https://jnm.snmjournals.org/content/56/7/989.full.pdf}, journal = {Journal of Nuclear Medicine} }