TY - JOUR T1 - Chemistry and Biology of Radiotracers That Target Changes in Sympathetic and Parasympathetic Nervous Systems in Heart Disease JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 7S LP - 10S DO - 10.2967/jnumed.114.142802 VL - 56 IS - Supplement 4 AU - William C. Eckelman AU - Vasken Dilsizian Y1 - 2015/06/01 UR - http://jnm.snmjournals.org/content/56/Supplement_4/7S.abstract N2 - Following the discovery of the sympathetic and parasympathetic nervous system, numerous adrenoceptor drugs were radiolabeled and potent radioligands were prepared in order to image the β-adrenergic and the muscarinic systems. But the greatest effort has been in preparing noradrenaline analogs, such as norepinephrine, 11C-metahydroxyephedrine, and 123I-metaiodobenzylguanidine that measure cardiac sympathetic nerve varicosities. Given the technical and clinical challenges in designing and validating targeted adrenoceptor-binding radiotracers, namely the heavily weighted flow dependence and relatively low target-to-background ratio, both requiring complicated mathematic analysis, and the inability of targeted adrenoceptor radioligands to have an impact on clinical care of heart disease, the emphasis has been on radioligands monitoring the norepinephrine pathway. The chemistry and biology of such radiotracers, and the clinical and prognostic impact of these innervation imaging studies in patients with heart disease, are examined. ER -