TY - JOUR T1 - Real-time portable gamma camera imaging for optimizing quality control during parenteral radiotherapy administration JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1252 LP - 1252 VL - 56 IS - supplement 3 AU - Chadwick Wright AU - Michael Knopp AU - Nathan Hall Y1 - 2015/05/01 UR - http://jnm.snmjournals.org/content/56/supplement_3/1252.abstract N2 - 1252 Objectives Samarium-153 (153Sm) and Yttrium-90 (90Y)-labeled ibritumomab tiuxetan are both beta-emitting intravenous radiotherapies used in patients with osseous metastases and CD20-positive lymphoma, respectively. Additional radiation is generated by 153Sm which produces photons that can be detected and imaged using conventional gamma cameras. Likewise, 90Y decay produces a continuous spectrum of bremsstrahlung radiation which can also be imaged. This study utilized real-time portable gamma camera imaging to rapidly verify systemic circulation during radiotherapy administration and exclude focal radiotherapeutic extravasation at the injection site.Methods Retrospective analysis was performed for all intravenous 153Sm and 90Y-ibritumomab tiuxetan administrations which were imaged using a large field-of-view portable gamma camera (Ergo, DigiRad) for the purposes of quality control and patient safety. Per our standard clinical protocol, dynamic imaging of the patient’s chest was performed to verify systemic circulation early during the intravenous administration. After completion of the radiotherapy administration and removal of the patient’s intravenous access, an additional static image of the intravenous access site was obtained to assess for focal extravasation.Results Two 153Sm and one 90Y-ibritumomab tiuxetan administrations were included. In all cases, dynamic chest imaging confirmed systemic activity early during the intravenous administration. There were no instances of focal extravasation of the radiotherapeutic at the intravenous access site.Conclusions The current findings demonstrate that systemic administrations of 153Sm and 90Y-ibritumomab tiuxetan can be imaged in real-time with a portable gamma camera. For the purposes of optimizing patient safety and quality control during intravenous radiotherapy administration, this simple imaging approach can be used to quickly confirm and even quantify systemic circulation early during injection period as well as exclude focal soft tissue extravasation. ER -