TY - JOUR T1 - Evaluation of lean body mass normalized standard uptake values in PET studies using a predictive equation. JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1787 LP - 1787 VL - 56 IS - supplement 3 AU - Yumiko Kono AU - Keita Utsunomiya AU - Noboru Tanigawa AU - Sang Kil Ha-Kawa AU - Yasuhiro Ueno Y1 - 2015/05/01 UR - http://jnm.snmjournals.org/content/56/supplement_3/1787.abstract N2 - 1787 Objectives To evaluate the accuracy of maximum standardized uptake value (SUVmax) and predictive equation estimated lean body mass (LBM) normalized SUV (SULPE) compared to measured LBM normalized SUV (SULS), the defined gold standard.Methods The subjects consisted 133 patients who had undergone FDG PET/CT imaging. The regions of interest (ROIs) were in the aorta (n=133) and the liver (n=131). Two patients were excluded from the liver VOI cohort due to multiple liver lesions. To calculate SULS, LBM was measured using a body fat analyzer. For SUVPE, the PE was used to estimate LBM. SUVmax, SUVS, and SUVPE were calculated from the same VOIs. The differences between SUVmax, SUVS, and SUVPE were compared for 3 groups: low body mass index (BMI <18.5), normal BMI (BMI 18.5-25), and high BMI (BMI >25).Results In the aortic and liver VOIs, SUVmax (mean±SE) were 2.04±0.29 and 2.50±0.28 in the low BMI group, 2.41±0.41 and 2.98±0.47 in the normal BMI group, and 2.71±0.28 and 3.42±0.41 in high BMI group, respectively. SULPE were 1.72±0.27 and 2.10±0.27 in the low BMI group, 1.90±0.35 and 2.36±0.44 in the normal BMI group, and 1.86±0.27 and 2.33±0.35 in the high BMI group, respectively. SUVS were 1.70±0.27 and 2.07±0.28 in the low BMI group, 1.82±0.30 and 2.25±0.36 in the normal BMI group, and 1.76±0.26 and 2.23±0.35 in the high BMI group. In both the aortic and liver ROIs, SUVmax was significantly higher (p<0.01) than SUVS and SULPE across all three BMI groups; SUVmax variation was on the order of 30% between the low and high BMI groups. SULPE correlated better with SUVS although mean SULPE was significantly higher than mean SUVS in the normal and high BMI groups.Conclusions SUVmax was found to be strongly dependent on patient weight with a systematic variation of about 30% across the three categories: low, normal, and high BMI. SUVPE should be considered as a clinical useful proxy measure of FDG uptake for the body-weight independent gold standard measure SUVS.Research Support None. ER -