PT  - JOURNAL ARTICLE
AU  - Iagaru, Andrei
AU  - Minamimoto, Ryogo
AU  - Jamali, Mehran
AU  - Barkhodari, Amir
AU  - Obara, Piotr
AU  - Loening, Andreas
AU  - Taviani, Valentina
AU  - Mittra, Erik
AU  - Gambhir, Sanjiv
AU  - Vasanawala, Shreyas
TI  - <strong>Imaging </strong><strong>patients with breast and prostate cancers using combined <sup>18</sup>F NaF/<sup>18</sup>F FDG and TOF simultaneous PET/ MRI</strong>
DP  - 2015 May 01
TA  - Journal of Nuclear Medicine
PG  - 1455--1455
VI  - 56
IP  - supplement 3
4099  - http://jnm.snmjournals.org/content/56/supplement_3/1455.short
4100  - http://jnm.snmjournals.org/content/56/supplement_3/1455.full
SO  - J Nucl Med2015 May 01; 56
AB  - 1455 Objectives We previously reported the evaluation of a simultaneous PET/MRI scanner with TOF capability, as well as the use of combined 18F NaF/18F FDG PET/CT in cancer patients. Here we compared the combined 18F NaF/18F FDG PET/ MRI against 99mTc-MDP in patients with breast and prostate cancers.Methods 9 patients referred for 99mTc-MDP bone scans were prospectively enrolled from Oct-Dec 2014. The cohort included 6 men with prostate cancer and 3 women with breast cancer, 41 - 85 year-old (average 64 ± 15). 18F NaF (0.7-2.2 mCi, mean: 1.33 mCi) and 18F FDG (3.9-5.2 mCi, mean: 4.6 mCi) were subsequently injected from separate syringes. The PET/MRI was done 6-12 days (average 9.3 ± 3.2) after bone scan. The whole body MRI protocol consisted of T2-weighted, SSFSE, DWI, and contrast-enhanced T1-weighted imaging. Lesions detected with each test were tabulated and the results were compared.Results All patients tolerated the PET/MRI exam, and PET image quality was diagnostic despite the marked reduction in the administered dosage of radiopharmaceuticals (80% less for 18F NaF and 67% less for 18F FDG). Two patients had no bone metastases identified on either scans. Bone scintigraphy and PET/MRI showed osseous metastases in 7 patients, but more numerous bone findings were noted on PET/MRI than on bone scintigraphy in 3 patients. Lesions outside the skeleton were identified by PET/MRI in 2 patients.Conclusions The combined 18F NaF/18F FDG PET/MRI is superior to 99mTc-MDP scintigraphy for evaluation of skeletal disease extent. Further, it detected extra-skeletal disease that may change the management of these patients, while allowing a significant reduction in radiation exposure from lower dosages of PET radiopharmaceuticals administered. A combination of 18F NaF/18F FDG PET/MRI may provide the most accurate staging of patients with breast and prostate cancers prior to the start of treatment.Research Support GE Healthcare