RT Journal Article SR Electronic T1 Evaluation of 2 diuretic 18F-FDG PET/CT imaging protocols for urinary bladder cancer JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1272 OP 1272 VO 56 IS supplement 3 A1 Lawrence Dierickx A1 Laurent Dercle A1 Leonor Chaltiel A1 Séverine Brillouet A1 Slimane Zerdoud A1 Erwann Gabiache A1 Olivier Caselles A1 Frédéric Courbon YR 2015 UL http://jnm.snmjournals.org/content/56/supplement_3/1272.abstract AB 1272 Objectives Urinary bladder activity restricts the application of FDG PET/CT for intrapelvic evaluation. We evaluate 2 different diuretic imaging protocols by comparing intensity of post-diuretic urinary activity and we look at the impact of multiple variables.Methods Prospective randomised analysis of 102 patients (mean age: 64) having primary or recurrent bladder carcinoma. After the full body acquisition, 58 patients were administered 20 mg of furosemide 90 min post injection of FDG (P90). For 44 patients, 20 mg of furosemide was administered 30 min post injection of FDG (P30). Comparisons between groups were performed using Mann-Whitney test for continuous variables and Chi-square for categorical variables. A multivariable analysis was performed for impact on final urinary activity using the SUVmax cut-off of 5,1 and following parameters: BMI, creatinine, creatinine clearance, age, injected dose, diuretic protocol, gender and glycemia.Results Concerning the comparison of the urinary activity we observe a significant difference (p 0.0029) between P90 and P30 for the SUVmax (median 4.3 (range 1.6: 17.7) vs 6.0 (range 2.9: 15.1)) and for the SUVmean (p<0,001) (median 2.4 (range 1.1; 9.9) vs 3.8 (range 2.0; 10.1)). For 2 patients of P30, the acquisition was interrupted because the patient needed to void. The multivariable analysis shows that the BMI or injected dose, glycemia, age and the diuretic protocol have a significant independant impact on the final bladder activity.Conclusions By comparing the 2 diuretic imaging protocols, we observe a significant lower urinary activity for P90 which is overall the more optimal protocol. The P30 protocol seems to be less well tolerated. A regression tree is proposed to identify patients who benefit from the P90 protocol. Only in the group of patients with an injected dose of less then 240 MBq and older than 65 years the P30 protocol can be used as an alternative, if P90 is not feasible.