TY - JOUR T1 - Diagnostic value of <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography for cutaneous lesions from extranodal natural killer/ T-cell lymphoma JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1366 LP - 1366 VL - 56 IS - supplement 3 AU - chang liu AU - Yingjian Zhang AU - Silong Hu AU - Yongping Zhang Y1 - 2015/05/01 UR - http://jnm.snmjournals.org/content/56/supplement_3/1366.abstract N2 - 1366 Objectives To evaluated the utility of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) scan in the diagnosis of cutaneous Extranodal natural killer/ T-cell lymphoma, Nasal Type (CNKTCL).Methods A total of 39 patients with extranodal natural killer (NK)/T-cell lymphoma, nasal-type (ENKTL) who had single skin symptom were enrolled between May 2009 and November 2013.They all had undergone both MR imaging and 18F-FDG PET/CT examinations before the skin lesion diagnosed. Biopsy was used as the gold standard for diagnosis.Results Of all the 39 eligible patients, 30 malignancy skin lesions were confirmed by histopathology. 18F-FDG PET/CT detected 28 lesions, while MR detected only 21 lesions. 18F-FDG PET/CT was superior to MR in 19 lesions without anatomic region-based abnormality [13⁄19 lesions (68.4%) vs. 7⁄19 lesions (36.8%), respectively; P= 0.013]. Univariate analysis showed that focal anatomical abnormality, pre-chemotherapy and EB virus infection were significant predictors of higher SUVmax, although only focal anatomical abnormality remained an independent determinant of higher SUVmax on multivariate analysis (p=0.027).Conclusions Our findings indicate that 18F-FDG PET/CT has an advantage over MR in the detection of CNKTCL, especially for the cutaneous lesions without anatomic region-based abnormality. ER -