%0 Journal Article %A sameer Taywade %A Rakesh Kumar %A Nishikant Damle %A Madhavi Tripathi %A Shamim Shamim %A Chandrasekhar Bal %T Role of 18F-FDG PET-CT in restaging of patients with primitive neuroectodermal tumor %D 2015 %J Journal of Nuclear Medicine %P 1421-1421 %V 56 %N supplement 3 %X 1421 Objectives The aim of the present study was to evaluate the role of 18F-FDG PET- CT (flurodeoxyglucose positron emission tomography - computed tomography) in restaging of patients with primitive neuroectodermal tumor (PNET) post surgery, chemotherapy or radiotherapy (RT).Methods A total of 34 patients of PNET previously treated with surgery, chemotherapy or RT who underwent 18F-FDG PET-CT for restaging were analysed retrospectively. Fifty seven 18F-FDG PET-CT studies were conducted on these patients. Out of these 34 patients, 20 patients underwent 18F-FDG PET-CT once, 9 patients twice, 2 patients thrice, 2 patients four times and 1 patient underwent this study five times. Mean age of patients was 18.6 years (range 5-55 years). 18F-FDG PET-CT study was evaluated by two nuclear medicine physician. Final diagnosis was made based on correlation with clinical, biopsy, follow up and other imaging modality.Results Of 34 patients, no active disease was found in 13 patients and 21 patients showed residual/recurrent disease on 18F-FDG PET-CT. Sites involved in residual/recurrent disease were - primary site of disease (35.2%), multiple skeletal sites (17.6%), lungs (14.7%), lymph nodes (11.7%) and bone marrow (5.8%). Active disease involving more than one system was detected in 7 patients (20.58%). Two patients (5.8 %) with suspicious residual active disease on 18F-FDG PET-CT were found normal on correlation with MRI and on follow up. Out of 34, 7 (20.58%) patients considered normal on 18F-FDG PET-CT were detected with residual/recurrent disease based on clinical, biopsy, follow up and other imaging modality correlation. The overall sensitivity, specificity, PPV, NPV of 18F-FDG PET-CT to detect active disease was 80%, 90.91%, 93.33 and 74.07 respectively.Conclusions 18F-FDG PET-CT can be a valuable modality to assess the post treatment disease status in patients with PNET, not only to evaluate the local site but to detect metastasis as well. %U