PT  - JOURNAL ARTICLE
AU  - Afshar-Oromieh, Ali
AU  - Kratochwil, Clemens
AU  - Benesova, Martina
AU  - Eder, Matthias
AU  - Kopka, Klaus
AU  - Neels, Oliver
AU  - Giesel, Frederik
AU  - Haberkorn, Uwe
TI  - The novel PSMA ligand DKFZ-617 in the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumor lesions
DP  - 2015 May 01
TA  - Journal of Nuclear Medicine
PG  - 398--398
VI  - 56
IP  - supplement 3
4099  - http://jnm.snmjournals.org/content/56/supplement_3/398.short
4100  - http://jnm.snmjournals.org/content/56/supplement_3/398.full
SO  - J Nucl Med2015 May 01; 56
AB  - 398 Objectives PET-imaging with inhibitors of the prostate-specific membrane antigen (PSMA) is regarded as a significant step forward in the diagnosis of prostate cancer (PCa). More recently, the small molecule PSMA-ligand DKFZ-617 with improved affinity and cellular internalization efficacy was identified which enables, both, diagnosis and therapy of PCa. Our first experience with DKFZ-617 suggests that this novel theranostic compound can detect PCa with high contrast. The aim of this evaluation was to investigate the biodistribution of DKFZ-617 in normal tissues and in PCa lesions.Methods 15 patients with recurrent PCa were referred to PSMA-ligand PET/CT with 68Ga-DKFZ-617. Quantitative assessment of tracer uptake was performed in 15 patients 1h and 3h p.i. by analysis of the standardized uptake value (SUV) of several organs and 29 representative tumor lesions.Results Intense tracer uptake was observed in kidneys and salivary glands. In 10 of 15 patients (66.7%) at least one tumor suspicious lesion was detected 3h p.i. Overall, 24 PCa lesions were visible at 1h p.i. and 29 at 3h p.i. Mean tumor-to-background ratios for SUVmax were 11.8 ± 6.0 (2.3 - 31.0) at 1h p.i. and 17.4 ± 10.4 (5.9 - 54.3) at 3h p.i.Conclusions Within healthy organs, kidneys and salivary glands demonstrated the highest 68Ga-DKFZ-617 uptake. Images conducted at 3h p.i. detected more tumor lesions compared to images at 1h p.i. Overall, 68Ga-DKFZ-617 can detect PCa lesions with high contrast.