TY - JOUR T1 - Tumor volume, FDG uptake, and Tumor dose in correlation with treatment volume change after Y-90 radioembolization in patients with hepatocellular carcinoma JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1239 LP - 1239 VL - 56 IS - supplement 3 AU - Mijin Yun AU - Sang Hyun Hwang AU - Yong Hoon Choi AU - Mi-Ae Park Y1 - 2015/05/01 UR - http://jnm.snmjournals.org/content/56/supplement_3/1239.abstract N2 - 1239 Objectives In patients with hepatocellular carcinoma (HCC), we estimated tumor volume on computed tomography (CT), F-18 Fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET/CT) at baseline, and tumor dose of Y-90 on PET/CT one day after Y-90 microsphere radioembolization (RE). We then assessed these variables in predicting tumor volume changes at 3months post-treatment.Methods We retrospectively analyzed contrast enhanced CT, FDG PET/CT, and Y-90 PET/CT images of 26 patients (F:M=6:20, a mean age of 55.6 yr) who underwent Y-90 RE. The percentage change of tumor volume (dV) from baseline to 3 months follow-up CT after RE was calculated. The maximum standardized uptake value (SUVmax) of the tumor was divided by the mean SUV of background liver (T/LSUV) on PET/CT. Voxel dosimetry was performed on Y90 PET/CT, and dose to the tumor and dose-volume histogram (DVH) were obtained. Tumor volume fraction received greater than 100Gy (TF100) was estimated from the DVH. Relationships between baseline tumor volume, T/LSUV at baseline, TF100, and dV were assessed by linear regression analyses.Results Baseline tumor volume showed a marginally significant inverse relationship with dV (r=0.383, p=0.053). T/LSUV also revealed an inverse relationship (r=0.499, p=0.009). In contrast, TF100 had a positive relationship with dV (r=0.496, p=0.01). In fact, TF100 showed significant inverse relationships with baseline tumor volume and T/LSUV (p<0.01 for each, r=0.552 for baseline tumor volume and r=0.499 for T/LSUV), suggesting better response to Y-90 RE in smaller tumors with lower FDG uptake.Conclusions TF100 calculated by Y-90 PET/CT based dosimetry showed a significant positive correlation with dV validating the role of TF100 in assuring tumor response. The tumor volumetric and metabolic biomarkers can be important in predicting TF100 after RE. Study summary (N=26) ER -