PT  - JOURNAL ARTICLE
AU  - Fan, Yang
AU  - Yang, Zhi
AU  - Wang, Xuejuan
TI  - Baseline total lesion glycolysis by positron emission tomography/ computed tomography as a best prognostic parameter for patients with primary thyroid lymphoma
DP  - 2015 May 01
TA  - Journal of Nuclear Medicine
PG  - 1373--1373
VI  - 56
IP  - supplement 3
4099  - http://jnm.snmjournals.org/content/56/supplement_3/1373.short
4100  - http://jnm.snmjournals.org/content/56/supplement_3/1373.full
SO  - J Nucl Med2015 May 01; 56
AB  - 1373 Objectives To analyze the prognostic significances of total lesion glycolysis (TLG), metabolic tumor burden (MTV), and maximum standardized uptake value (SUVmax) in patients with primary thyroid lymphoma (PTL).Methods Seventeen patients with PTL were histologically diagnosed in 1141 lymphoma patients. Baseline18F-FDG PET/CT scan was performed before therapy. TLGs, MTVs, and SUVs were calculated with the margin thresholds as 42% or 50% of SUVmax. Clinical outcomes were compared between metabolic parameters and prognostic factors.Results Of nine quantitative parameters, only TLG50 of the whole body (TLG50whole) was significantly associated with treatment outcomes (P<0.05). High TLG50whole have been related with adverse prognostic factors (2-year PFS of 60±22 % versus 100 %, P=0.027; and 2-year OS of 53±25 % versus 100 %, P=0.023). SUVmax, MTVs, and clinical factors had no correlate with outcomes in PTL patients (P>0.05).Conclusions Our preliminary results indicated the baseline TLG50whole might help predicting the outcomes of PTL patients. Univariate analysis using Kaplan-Meier survival curves analysis