RT Journal Article
SR Electronic
T1 Inflammatory activity in oral cavity is associated with carotid plaque inflammation regardless of systemic inflammation
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1507
OP 1507
VO 56
IS supplement 3
A1 Soyeon Park
A1 Taegyu Park
A1 Eunsub Lee
A1 Jae Seon Eo
A1 Kisoo Pahk
A1 Seunghong Rhee
A1 Jaehyuk Cho
A1 Jae Gol Choe
A1 Sungeun Kim
YR 2015
UL http://jnm.snmjournals.org/content/56/supplement_3/1507.abstract
AB 1507 Objectives Periodontitis is one of candidates associated with elevated levels of C-reactive protein(CRP) and other inflammatory biomarkers. Epidemiologic studies have shown that periodontitis is associated with endothelial dysfunction, atherosclerosis and increased risk of coronary heart disease and stroke. We aimed to investigate the relation between periodontitis and inflammation of the carotid artery.Methods We observed 86 patients with clinical diagnosis of periodontitis and 42 subjects without it. All subjects underwent F-18 fluorodeoxyglucose(FDG) positron emission tomography/computed tomography and were evaluated for the level of inflammation using the maximum standardized uptake value(maxSUV) of FDG in the right carotid artery and the dental region.Results The patients with periodontitis showed significantly higher SUV of dental region(2.8±0.4 vs. 1.2±0.7, p< 0.001) and right carotid artery(2.5±0.4 vs. 0.8± 0.7, p< 0.001) and high-sensitivity CRP(hsCRP)(2.18±3.10 mg/l vs. 1.20±1.12 mg/l, p=0.014) than control. The correlation of dental SUV was very high with carotid artery SUV(r=0.851, p< 0.001) but modest with hsCRP(r=0.179, p=0.51). The hsCRP showed no correlation with carotid artery SUV(r=0.096, p=0.301). In multiple linear regression analysis, carotid SUV was significantly associated with periodontitis(R2=0.730, p< 0.001) or dental SUV(R2=0.763, p< 0.001) independent of age, sex, hsCRP or other covariates.Conclusions Independent of systemic inflammation, these data suggest that periodontitis per se and its degree of inflammation appear to be closely associated with vascular inflammation, a crucial mechanism of the development, progression and vulnerability of atherosclerotic plaque.