PT - JOURNAL ARTICLE AU - Soyeon Park AU - Taegyu Park AU - Eunsub Lee AU - Jae Seon Eo AU - Kisoo Pahk AU - Seunghong Rhee AU - Jaehyuk Cho AU - Jae Gol Choe AU - Sungeun Kim TI - Inflammatory activity in oral cavity is associated with carotid plaque inflammation regardless of systemic inflammation DP - 2015 May 01 TA - Journal of Nuclear Medicine PG - 1507--1507 VI - 56 IP - supplement 3 4099 - http://jnm.snmjournals.org/content/56/supplement_3/1507.short 4100 - http://jnm.snmjournals.org/content/56/supplement_3/1507.full SO - J Nucl Med2015 May 01; 56 AB - 1507 Objectives Periodontitis is one of candidates associated with elevated levels of C-reactive protein(CRP) and other inflammatory biomarkers. Epidemiologic studies have shown that periodontitis is associated with endothelial dysfunction, atherosclerosis and increased risk of coronary heart disease and stroke. We aimed to investigate the relation between periodontitis and inflammation of the carotid artery.Methods We observed 86 patients with clinical diagnosis of periodontitis and 42 subjects without it. All subjects underwent F-18 fluorodeoxyglucose(FDG) positron emission tomography/computed tomography and were evaluated for the level of inflammation using the maximum standardized uptake value(maxSUV) of FDG in the right carotid artery and the dental region.Results The patients with periodontitis showed significantly higher SUV of dental region(2.8±0.4 vs. 1.2±0.7, p< 0.001) and right carotid artery(2.5±0.4 vs. 0.8± 0.7, p< 0.001) and high-sensitivity CRP(hsCRP)(2.18±3.10 mg/l vs. 1.20±1.12 mg/l, p=0.014) than control. The correlation of dental SUV was very high with carotid artery SUV(r=0.851, p< 0.001) but modest with hsCRP(r=0.179, p=0.51). The hsCRP showed no correlation with carotid artery SUV(r=0.096, p=0.301). In multiple linear regression analysis, carotid SUV was significantly associated with periodontitis(R2=0.730, p< 0.001) or dental SUV(R2=0.763, p< 0.001) independent of age, sex, hsCRP or other covariates.Conclusions Independent of systemic inflammation, these data suggest that periodontitis per se and its degree of inflammation appear to be closely associated with vascular inflammation, a crucial mechanism of the development, progression and vulnerability of atherosclerotic plaque.