RT Journal Article
SR Electronic
T1 <strong>Correlation Study of <sup>18</sup>F-FDG PET-CT SUV<sub>max</sub>, ER, PR, HER-2, Ki-67 and p53 during neoadjuvant chemotherapy in breast cancer</strong>
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1313
OP 1313
VO 56
IS supplement 3
A1 LI, WEN
A1 Feng, Yan-lin
YR 2015
UL http://jnm.snmjournals.org/content/56/supplement_3/1313.abstract
AB 1313 Objectives Comparison of the statistical difference between maximum standard uptake value (SUVmax) before neoadjuvant chemotherapy(NAC), SUVmax change rate(⊿SUVmax1%) after the first cycle of NAC , SUVmax change rate(⊿SUVmax2%) after the second cycle of NAC and status of ER, PR, HER-2, Ki-67, p53 expression in breast cancer.To explore the inner link between FDG uptake and molecular biological markers.Methods Retrospective study of 211 cases of newly diagnosed breast cancer patients which performed 18F-FDG PET-CT at the baseline, 49 cases performed PET-CT after the first cycle of NAC, 49 cases performed PET-CT after the second cycle of NAC. The SUVmax and the rate of change was calculated. Tissue specimens from patients were immunohistochemically stained for ER, PR, HER-2, Ki-67 and p53.Results The results show (Table 1), SUVmax in ER negative group was significantly higher than in ER positive group (p=0.000). SUVmax in PR negative group was significantly higher than in PR positive group (p=0.001). ⊿SUVmax2% in PR negative group was higher than in PR positive group(p=0.026). SUVmax, ⊿SUVmax2% in Ki-67 positive group was higher than in Ki-67 negative group(p=0.000, 0.022 respectively). There was no statistically difference among SUVmax, ⊿SUVmax1%, ⊿SUVmax2% in p53 and HER-2 negative group and in p53 and HER-2positive group (p=0.561, 0.920, 0.594 respectively).Conclusions FDG metabolic of ER, PR negative patients was higher than ER, PR positive patients. ⊿SUVmax2% in PR negative patients was higher than PR positive patients, it suggests PR negative patients are more sensitive to NAC. SUVmax of Ki-67 positive group was higher than Ki-67 negative group, suggesting FDG metabolic may reflect the proliferation of tumor. Ki-67 positive patients had a higher ⊿SUVmax2%, it means Ki-67 positive patients are more sensitive to NAC. Table 1 The correlation between SUVmax、⊿SUVmax1%、⊿SUVmax2% with the expression of ER、PR、HER-2、Ki-67、P53