RT Journal Article SR Electronic T1 Increased Cardiac 11C-Hydroxyephedrine (HED) washout using compartment model analysis in patients with heart failure. JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1764 OP 1764 VO 56 IS supplement 3 A1 Yuuki Tomiyama A1 Keiichiro Yoshinaga A1 Chietsugu Katoh A1 Mamoru Sakakibara A1 Katsuhiko Kasai A1 Osamu Manabe A1 Masanao Naya A1 Ken-ichi Nishijima A1 Nagara Tamaki YR 2015 UL http://jnm.snmjournals.org/content/56/supplement_3/1764.abstract AB 1764 Objectives 11C-Hydroxyephedrine (HED) has been the most frequently used PET tracer for cardiac sympathetic nervous system (SNS) estimation. The norepinephrine wash out from myocaridium is associated with increasing SNS activity and poor outcomes in heart failure (HF). However, the HED wash out is controversial. Although "Retention Index" (RI) is commonly used to quantify uptake of HED, RI is not able to distinguish between pure washout parameter and uptake parameter. Thus, the purpose of this study was to evaluate whether HED was washed out from the myocardium. Therefore, we analyzed washout parameter of HED using compartment model analysis in HF patients.Methods We compared HED PET/CT parameters in 9 HF patients (Age: 57.3 ± 17.3 y, LVEF: 36.1±16.7 %) and 10 normal individuals (32.4 ± 9.6 y). Each subjects underwent rest 11C-HED PET/CT. We computed RI, inflow rate K1 and washout rate k2 using single compartment model analysis.Results HF patients showed lower RI and inflow rate K1 comapred to normal individuals (RI: 0.06 ± 0.02 vs. 0.15 ± 0.03 min-1, p < 0.001, K1: 0.14 ± 0.05 vs. 0.20 ± 0.03 ml/min/g, p < 0.001). Washout rate k2 also significantly increased in HF patients (k2: 0.036 ± 0.026 vs. 0.016 ± 0.011 min-1, p = 0.041).Conclusions HF patients showed reduced RI, reduced K1 and higher washout rate of k2 compared to normal. Thus, HED PET may be able to evaluate washout parameter using compartment model. Using compartment model, HED PET/CT may also provide additional prognostic information over RI.