@article {Matesan1757, author = {Manuela Matesan and Donna Cross and Satoshi Minoshima}, title = {Stereotactic Image Registration Using Multimodal Image Templates: Application to Dopamine Transporter SPECT}, volume = {56}, number = {supplement 3}, pages = {1757--1757}, year = {2015}, publisher = {Society of Nuclear Medicine}, abstract = {1757 Objectives Reliable stereotactic image registration for brain molecular images that have distinct tracer distributions in normals vs. abnormals (i.e., dopamine transporter SPECT (DAT) and amyloid PET) is challenging. We developed a new registration method that uses multimodal image templates and tested for [I-123]ioflupane SPECT.Methods The new algorithm optimizes image transformation using multimodal stereotactic image templates and multi-dimensional mutual information. The target image set is iteratively deformed nonlinearly and matched simultaneously with the multiple templates. Thirty DAT scans (10 normals vs 20 abnormals) were selected randomly from our database for testing. Four approaches with different combination of templates were tested 1) normal DAT template [D]; 2) normal FDG PET template, representing general cortical and subcortical uptake [F]; 3) normal DAT+normal FDG PET [DF]; and 4) normal DAT+abnormal DAT+normal FDG PET [D2F]. Stereotactically transformed image sets were pixel-normalized to the global count and averaged across subjects for assessments.Results Peak normalized values of the striatum were 2.202; 2.475; 2.362; and 2.300 by the approach [D], [F], [DF], and [D2F], respectively. When compared to [D] (normal DAT template alone), the peak values increased 12\%, 7\%, and 4\% by [F], [DF], and [D2F], respectively, indicating better spatial alignment. Peak coefficients of variation decreased 5\% by [DF], but increased 29\% and 17\% by [F] and [D2F,] respectively. When using one or two templates ([D], [F,] and [DF]), the method completed transformation in all cases (normals and abnormals), improved group distinctions, but [D2F] failed to find the final solution in 2 cases due to local minima.Conclusions The simultaneous use of normal DAT SPECT and FDG PET templates, instead DAT template alone, permitted improved image registration for DAT SPECT with the lowest striatal variance. The method should facilitate subsequent quantitative assessments using predefined stereotactic ROI or voxel-based analyses.}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/56/supplement_3/1757}, eprint = {https://jnm.snmjournals.org/content}, journal = {Journal of Nuclear Medicine} }