RT Journal Article
SR Electronic
T1 A theranostic approach for adrenocortical neoplasia based on high adrenal CXCR4 expression.
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 145
OP 145
VO 56
IS supplement 3
A1 Bluemel, Christina
A1 Lapa, Constantin
A1 Schirbel, Andreas
A1 Fassnacht, Martin
A1 Allolio, Bruno
A1 Schottelius, Margret
A1 Kropf, S.
A1 Wester, Hans
A1 Hahner, Stefanie
A1 Herrmann, Ken
YR 2015
UL http://jnm.snmjournals.org/content/56/supplement_3/145.abstract
AB 145 Objectives The chemokine receptor CXCR4 is a key factor for tumor growth and metastasis in several human cancers. Recently, [68Ga]Pentixafor has been developed as a PET tracer specifically targeting CXCR4. The aim of this study was to evaluate the suitability of [68Ga]Pentixafor for in vivo imaging of patients with adrenocortical carcinoma (ACC) and selecting potential patients for future CXCR4-directed treatments.Methods 22 consecutive patients (12 female, 10 male; mean age 50.3±10.1 years) with histopathologically proven metastasized ACC were examined with [68Ga]Pentixafor, a specific CXCR4 PET-ligand. Imaging results were compared to [18F]FDG PET/CT.Results Visual comparison of both tracers resulted in comparable findings in 7 (32%) patients. In 9 patients (41%) [18F]FDG identified more lesions with visually higher uptake compared to [68Ga]Pentixafor. In 2 patients (9%) [68Ga]Pentixafor identified more metastatic lesions than [18F]FDG, whereas in 4 patients (18%) [68Ga]Pentixafor and [18F]FDG provided complementary information regarding the number and intensity of lesions. Including patients history and the results of the [68Ga]Pentixafor scan, 12 out of 22 patients (54%) were rated as suitable and 3 patients (14%) as potentially suitable peptide receptor radionuclide therapy (PRRT) with with [177Lu]/[90Y]-labeled Pentixafor analogs.Conclusions CXCR4 is highly expressed in a subgroup of ACC patients potentially contributing to the malignant behaviour of this neoplasia. [68Ga]Pentixafor-PET imaging provides excellent imaging quality and allows for selection of patients potentially qualifying for a CXCR4-directed PRRT.