RT Journal Article
SR Electronic
T1 Qualification of <sup>68</sup>Ge/<sup>68</sup>Ga generators: a comparison of organic matrix and tin oxide based generators
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1055
OP 1055
VO 56
IS supplement 3
A1 Niculae, Dana
A1 Niculae, Adrian
YR 2015
UL http://jnm.snmjournals.org/content/56/supplement_3/1055.abstract
AB 1055 Objectives The 68Ga generators of a chromatographic type is a glass or polypropylene column with a sorbent based on Al/ Zr/ Ti/ Sn/ Sb-oxides or organic matrix. The study compare the qualification steps and highlight the different approach for 2 different types of generators.Methods We have tested the generators (n=4) over 12 months, following the yield, elution profile, and also the labelling parameters and radiopharmaceutical preparation time. Ge-68 content was determined using an ionization chamber. The 68Ga solutions eluted in fractions from organic matrix generator, were used without any chemical changes, while the eluates from tin oxide based generator are usually containing small amounts of other cations (Ge, Fe, Sn, Zn) and should be purified prior the radiolabelling of peptides.Radiolabelling was performed in an automated synthesis module.Results The average elution yield of organic matrix generators was over 90%, with 75% of the activity in 2 mL eluate; 68Ge content in the eluate was stable over 1 year in the range 0.003-0.004%. The elution yield of the tin oxide based generators is highly dependent on HCl concentration, from 80% with 0.6 M HCl up to 92% with 1 M HCl. Ge-68 in the eluate was rised from 0.002 % up to 0.026 % at 1 year after the first elution.Total synthesis time was 20 min and 35 min repectively.Conclusions Different type of generators require different post processing approach to use the eluate for peptides labelling. The 68Ge/68Ga generator, silica-based organic resin column is giving good elution yield; fractionated elution was used to concentrate the radioactivity and lowering the Ge-68 content, resulting in shorter synthesis and purification time. The 68Ge/68Ga generator, tin dioxide column is giving still good elution yield, but post processing of the eluate is needed, thus longer synthesis and purification time also the content of Ge-68 is higher than required.Research Support IAEA CRP 16500 and Partnership in priority areas PNII, MEN-UEFISCDI contract 228/2014