PT - JOURNAL ARTICLE AU - Nobutoku Motomura AU - Kenji Kuse AU - Jyoji Nakagawara AU - Hidehiro Iida TI - Evaluation of a triple-head SPECT system using high-sensitivity collimators and an iterative reconstruction method for brain studies DP - 2015 May 01 TA - Journal of Nuclear Medicine PG - 1858--1858 VI - 56 IP - supplement 3 4099 - http://jnm.snmjournals.org/content/56/supplement_3/1858.short 4100 - http://jnm.snmjournals.org/content/56/supplement_3/1858.full SO - J Nucl Med2015 May 01; 56 AB - 1858 Objectives While a high-sensitivity collimator increases sensitivity, spatial resolution is degraded. However, by using an iterative reconstruction method with a collimator blurring model (3D OSEM), spatial resolution can be improved. Thus, we have developed a tripe-head SPECT with high-sensitivity fan-beam (HS-fan) collimators and a 3D OSEM method to reduce scan time without degrading spatial resolution. In this work, the SPECT system was evaluated using phantoms and normal volunteers.Methods We used a triple-head SPECT system equipped with HS-fan collimators. The 3D OSEM method was used for reconstruction with 10 iterations and 10 subsets. Three types of brain phantoms were used for study simulation: Hoffman 3D brain and 3D brain phantoms for cerebral blood flow (CBF) and Striatal phantom for dopamine transporter (DAT). In normal volunteer studies, 99mTc ECD for CBFand 123IIoflupane for DAT were administered. Dynamic SPECT mode was used to create different scan time data sets. For comparison, data from a dual-head SPECT system with high-resolution parallel-beam (HR-para) collimators and reconstructed by the FBP method was used.Results In all three brain phantom studies, the 3D OSEM method showed improved spatial resolution. In the Striatal phantom, the putamen and caudate nucleus were separated more clearly. In normal volunteer studies, the triple-head SPECT data showed much higher spatial resolution than the dual-head data, as demonstrated in the separation of right and left thalamus (CBF) and of putamen and caudate nucleus (DAT). The shortest scan times for obtaining images with diagnostic quality were 5 minutes for CBF and 7 minutes for DAT. These scan times indicate a reduction by factors of three or more in contrast to the dual-head SPECT.Conclusions The triple-head SPECT system with HS-fan collimators and the 3D OSEM method was evaluated using phantoms and healthy volunteers. It was indicated that the SPECT system can reduce scan time while maintaining high image quality.