TY - JOUR T1 - Left ventricular volumes are different with PET vs SPECT myocardial perfusion imaging JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1765 LP - 1765 VL - 56 IS - supplement 3 AU - Timothy Miao AU - Vinay Kansal AU - Benjamin Chow AU - R. Glenn Wells AU - Terrence Ruddy AU - Robert deKemp Y1 - 2015/05/01 UR - http://jnm.snmjournals.org/content/56/supplement_3/1765.abstract N2 - 1765 Objectives Normal reference values for left ventricular (LV) volumes using Rb-82 PET and Tc-99m SPECT have not been well established. The purpose of this investigation is to establish and compare normal reference ranges for LV measurements by Rb-82 PET and SPECT with sodium iodide (NaI) and cadmium-zinc-telluride (CZT) gamma cameras.Methods Consecutive patients who underwent Rb-82 PET and Tc-99m tetrofosmin SPECT myocardial perfusion imaging were screened. Patients with a history of myocardial infarction, coronary revascularization, abnormal myocardial perfusion imaging or known LV dysfunction/reduced ejection fraction (EF) were excluded. A total of 2267 normal patients (1945 SPECT and 322 PET) with LV end diastolic volume (EDV) and end systolic volume (ESV) measurements were analyzed. After stratifying according to sex, LV volumes indexed to body surface area (BSA) were compared across the different modalities and gamma cameras.Results PET measured lower EDVi than both the CZT and NaI-based SPECT gamma cameras (40.4±8.6mL/m2 vs. 53.6±10.4mL/m2 and 48.6±10.1mL/m2 for men and 33.1±7.9mL/m2 vs. 43.3±8.9mL/m2 and 37.8±9.3mL/m2 for women; p<0.001). PET measured lower ESVi for CZT but higher ESVi for NaI (18.1±5.5mL/m2 vs. 21.7±7.0mL/m2 and 17.0±6.1mL/m2 for men and 12.6±4.8mL/m2 vs. 13.4±5.3mL/m2 and 10.7±5.0mL/m2 for women; p<0.001). PET measured lower EF compared to both CZT and NaI (56±8% vs. 60±7% and 66±8% for men and 62±8% vs. 70±7% and 73±9% for women; p<0.001).Conclusions This study establishes normal references ranges for Rb-82 PET and SPECT measures of LV volumes for site- and equipment-specific evaluations. Reference ranges of LV dimensions for PET and SPECT (CZT and NaI gamma cameras)EDVi, End diastolic volume index; ESVi, end systolic volume index; LVEF, left ventricular ejection fraction; CZT, cadmium-zinc-telluride gamma camera; NaI, sodium iodide gamma camera. Reference ranges are expressed as (mean-2SD to mean+2SD). ER -