RT Journal Article SR Electronic T1 Toward Radioguided Surgery with β− Decays: Uptake of a Somatostatin Analogue, DOTATOC, in Meningioma and High-Grade Glioma JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 3 OP 8 DO 10.2967/jnumed.114.145995 VO 56 IS 1 A1 Francesco Collamati A1 Alessandra Pepe A1 Fabio Bellini A1 Valerio Bocci A1 Giacomo Chiodi A1 Marta Cremonesi A1 Erika De Lucia A1 Mahila E. Ferrari A1 Paola M. Frallicciardi A1 Chiara M. Grana A1 Michela Marafini A1 Ilaria Mattei A1 Silvio Morganti A1 Vincenzo Patera A1 Luca Piersanti A1 Luigi Recchia A1 Andrea Russomando A1 Alessio Sarti A1 Adalberto Sciubba A1 Martina Senzacqua A1 Elena Solfaroli Camillocci A1 Cecilia Voena A1 Davide Pinci A1 Riccardo Faccini YR 2015 UL http://jnm.snmjournals.org/content/56/1/3.abstract AB A novel radioguided surgery (RGS) technique for cerebral tumors using β− radiation is being developed. Checking for a radiotracer that can deliver a β− emitter to the tumor is a fundamental step in the deployment of such a technique. This paper reports a study of the uptake of 90Y-DOTATOC in meningiomas and high-grade gliomas (HGGs) and a feasibility study of the RGS technique in these types of tumor. Estimates were performed assuming the use of a β− probe under development with a sensitive area 2.55 mm in radius to detect 0.1-mL residuals. Methods: Uptake and background from healthy tissues were estimated on 68Ga-DOTATOC PET scans of 11 meningioma patients and 12 HGG patients. A dedicated statistical analysis of the DICOM images was developed and validated. The feasibility study was performed using full simulation of emission and detection of the radiation, accounting for the measured uptake and background rate. Results: All meningioma patients but one with an atypical extracranial tumor showed high uptake of DOTATOC. In terms of feasibility of the RGS technique, we estimated that by administering a 3 MBq/kg activity of radiotracer, the time needed to detect a 0.1-mL remnant with 5% false-negative and 1% false-positive rates is less than 1 s. Actually, to achieve a detection time of 1 s the required activities to administer were as low as 0.2–0.5 MBq/kg in many patients. In HGGs, the uptake was lower than in meningiomas, but the tumor-to-nontumor ratio was higher than 4, which implies that the tracer can still be effective for RGS. It was estimated that by administering 3 mBq/kg of radiotracer, the time needed to detect a 0.1-mL remnant is less than 6 s, with the exception of the only oligodendroma in the sample. Conclusion: Uptake of 90Y-DOTATOC in meningiomas was high in all studied patients. Uptake in HGGs was significantly worse than in meningiomas but was still acceptable for RGS, particularly if further research and development are done to improve the performance of the β− probe.